When a spatially-inhomogeneous vortex laser field irradiating an epsilon-near-zero (ENZ) material is theoretically investigated, second-order vortex harmonics occur due to the symmetry breaking from the field spatial-inhomogeneity. Their signal intensity is sensitive to three factors: ENZ field enhancing ratio, the ENZ material thickness, and the field inhomogeneity degree. Their competition supports a high conversion efficiency of around 10-6 for second order harmonics from the incident fundamental laser field under an optimum thickness of ENZ materials.