Determining issues of importance for patients with breast cancer: Results of a web-based study in 1,072 patients to enhance the content validity for the development of a new health-related quality of life (QL) instrument, the Breast Cancer Symptom Scale (BCSS)

Abstract

e20615 Background: Identifying key issues for patients with malignancy is central to assessing QL and patient reported outcomes during all points of the illness trajectory. The involvement of patients in establishing content validity is crucial for instrument development. The conceptual model for the BCSS focuses on areas of importance for patients (Hollen, Supp Care Ca 1994). Methods: We used the established patient base of the web-based NexCura information resource to survey registered patients with breast cancer. Demographic stratifications included disease stage, age, menopausal status, time since diagnosis, prior/current treatment with surgery, RT, chemotherapy, hormonal, targeted, and CAM approaches. 1072 patients (median age 53, 65% stage I, 43% > 2 years since diagnosis) completed the anonymous web-conducted survey. Patients ranked 21 issues on a 5-point scale, assessing the importance of each item. Issues included general, physical, functional, psychosocial and summative items. Results: The 9 highest ranked items are seen below. Results are described by the percent of patients choosing the top category (very important) and the top 2 importance categories. The five lowest ranked items dealt with appetite, breast-specific issues, hot flashes and sexuality. Ratings by breast cancer subsets (newly diagnosed, on treatment, NED, hormonal or non-hormonal treatment, metastatic disease, survivors) showed some differences compared with the whole group. Conclusions: These results represent one of the largest surveys of concerns expressed by patients with breast cancer and support using computer-assisted technology to assess such information for rapid input of large patient samples. This study gives strong support for content validity for the BCSS and provides data on which to base separate QL instruments for specific breast cancer settings. [Table: see text] [Table: see text]

Health-related quality of life in women with breast cancer: a review of measures

“…▪ Conceptual relevance was supported for most items in both questionnaires based on patients’ reports of experiencing the concepts as part of their breast cancer experience. YW-BCI36 Christophe et al [ 35 ] ▪ Internal consistency (Cronbach alpha values ranging from 0.76 to 0.91) ▪ Temporal reliability (Bravais-Pearson correlations ranging from 0.66 to 0.85) ▪ As expected, there were quite strong correlations between the Young Women With Breast Cancer Inventory and the QLQ-C30 and QLQ-BR23 scores (r ranging from 0.20 to − 0.66), indicating adequate concurrent validity Breast Cancer Symptom Scale Horigan et al [ 36 ] ▪ NR ▪ The 9 highest ranked items include: good QoL, maintaining independence, able to sleep, able to concentrate, perform normal activities, being fatigued, having depression, being anxious, and having pain. ▪ The 5 lowest ranked items include: appetite, breast-specific issues, hot flashes, and sexuality.…”

“…Horigan et al [ 36 ] conducted a large survey of registered patients with breast cancer to further document the content validity of the BCSS. Specifically, the patients were asked to rank 21 issues identified as important to them.…”

Health-related quality of life in women with breast cancer: A review of measures

“…Horigan et al [36] conducted a large survey of registered patients with breast cancer to further document the content validity of the BCSS. Speci cally, the patients were asked to rank 21 issues identi ed as important to them.…”