Determining levels of linguistic deficit by applying cluster analysis to the aphasia quotient of Western Aphasia Battery in post-stroke aphasia

Yan, Zhijie; Wei, Dongshuai; Zhang, Jingna; Yang, Chun-Sheng; He, Xinyuan; Li, Chong; Zhang, Yongli; Chen, Mengye; Li, Xiaofang; Jia, Jie

doi:10.1038/s41598-022-17997-0

Cited by 3 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, the evaluator provided scores of fluency and information content, which were added together to obtain the score of spontaneous speech, according to the scoring standards of WAB after the patient answered the questions. Combined with symptoms, medical history, and imaging data, stroke patients with a WAB-AQ lower than 93.8 points were judged as PSA, and the lower the WAB-AQ, the more severe the aphasia ( Kertesz and Poole, 2004 ; Yan et al, 2022a ). The secondary outcome measures included the Montreal Cognitive Assessment (MoCA), Fugl-Meyer Assessment (FMA), and Barthel Index (BI), which were selected to evaluate the cognitive function, motor function, and activities of daily living, respectively ( Shah et al, 1989 ; Gladstone et al, 2002 ; Nasreddine et al, 2005 ).…”

Section: Methodsmentioning

confidence: 99%

Clinical study of melodic intonation therapy combined with transcranial direct current stimulation for post-stroke aphasia: a single-blind, randomized controlled trial

Yan

Cheng

et al. 2023

Front. Neurosci.

Self Cite

View full text Add to dashboard Cite

BackgroundGlobally, more than 10 million new stroke cases occur annually, of which aphasia accounts for about one-third. Aphasia has become an independent predictor of functional dependence and death for the stroke population. The closed-loop rehabilitation of combining behavioral therapy with central nerve stimulation seems to be the research trend of post-stroke aphasia (PSA) due to its advantages in improving linguistic deficits.ObjectiveTo verify the clinical efficacy of a closed-loop rehabilitation program combining melodic intonation therapy (MIT) with transcranial direct current stimulation (tDCS) for PSA.MethodsThis was a single-center, assessor-blinded, randomized controlled clinical trial, which screened 179 patients and included 39 PSA subjects, with the registration number ChiCTR2200056393 in China. Demographic and clinical data were documented. The primary outcome was the Western Aphasia Battery (WAB) used to assess language function, and the secondary outcomes included Montreal Cognitive Assessment (MoCA), Fugl-Meyer Assessment (FMA), and Barthel Index (BI) for evaluating cognition, motor, and activities of daily living, respectively. With the computer-generated randomization sequence, subjects were randomly divided into the conventional group (CG), MIT combined with sham stimulation group (SG), and MIT combined with tDCS group (TG). After the three-week intervention, the functional changes in each group were analyzed by the paired sample T-test, and the functional difference between the three groups was analyzed by ANOVA.ResultsThere was no statistical difference on the baseline. After the intervention, the WAB’s aphasia quotient (WAB-AQ), MoCA, FMA, and BI were statistically different in SG and TG, including all the sub-items in WAB and FMA, while only listening comprehension, FMA, and BI were statistically different in CG. The differences of WAB-AQ, MoCA, and FMA were statistically different among the three groups, but BI was not. The post hoc test results revealed that the changes of WAB-AQ and MoCA in TG were more significant than the others.ConclusionMIT combined with tDCS can augment the positive effect on language and cognitive recovery in PSA.

show abstract

Section: Methodsmentioning

confidence: 99%

Clinical study of melodic intonation therapy combined with transcranial direct current stimulation for post-stroke aphasia: a single-blind, randomized controlled trial

Yan

Cheng

et al. 2023

Front. Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…For example, the evaluator provided scores of fluency and information content, which were added together to obtain the score of spontaneous speech, according to the scoring standards of WAB after the patient answered the questions. Combined with symptoms, medical history, and imaging data, stroke patients with a WAB-AQ lower than 93.8 points were judged as PSA, and the lower the WAB-AQ, the more severe the aphasia (Kertesz and Poole, 2004;Yan et al, 2022a). The secondary outcome measures included the Montreal Cognitive Assessment (MoCA), Fugl-Meyer Assessment (FMA), and Barthel Index (BI), which were selected to evaluate the cognitive function, motor function, and activities of daily living, respectively Gladstone et al, 2002;.…”

Section: Outcome Measuresmentioning

confidence: 99%

Novel Technologies Targeting the Rehabilitation of Neurological Disorders

2024

Frontiers Research Topics

View full text Add to dashboard Cite

Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

show abstract

Clinical phenotypes of patients with acute stroke: a secondary analysis

Hajiesmaeili,

Nooraei,

Alamdari

et al. 2024

Romanian Journal of Internal Medicine

View full text Add to dashboard Cite

Introduction Stroke is a leading cause of mortality worldwide and a major cause of disability having a high burden on patients, society, and caregiving systems. This study was conducted to investigate the presence of clusters of in-hospital patients with acute stroke based on demographic and clinical data. Cluster analysis reveals patterns in patient characteristics without requiring knowledge of a predefined patient category or assumptions about likely groupings within the data. Methods We performed a secondary analysis of open-access anonymized data from patients with acute stroke admitted to a hospital between December 2019 to June 2021. In total, 216 patients (78; 36.1% men) were included in the analytical dataset with a mean (SD) age of 60.3 (14.4). Many demographic and clinical features were included in the analysis and the Barthel Index on discharge was used for comparing the functional recovery of the identified clusters. Results Hierarchical clustering based on the principal components identified two clusters of 109 and 107 patients. The clusters were different in the Barthel Index scores on discharge with the mean (SD) of 39.3 (29.3) versus 62.6 (29.4); t (213.87) = −5.818, P <0.001, Cohen’s d (95%CI) = −0.80 (−1.07, −0.52). A logistic model showed that age, systolic blood pressure, pulse rate, D-dimer blood level, low-density lipoprotein, hemoglobin, creatinine concentration, the National Institute of Health Stroke Scale value, and the Barthel Index scores on admission were significant predictors of cluster profiles (all P ≤0.029). Conclusion There are two clusters in hospitalized patients with acute stroke with significantly different functional recovery. This allows prognostic grouping of hospitalized acute stroke patients for prioritization of care or resource allocation. The clusters can be recognized using easily measured demographic and clinical features.

show abstract

Determining levels of linguistic deficit by applying cluster analysis to the aphasia quotient of Western Aphasia Battery in post-stroke aphasia

Cited by 3 publications

References 24 publications

Clinical study of melodic intonation therapy combined with transcranial direct current stimulation for post-stroke aphasia: a single-blind, randomized controlled trial

Clinical study of melodic intonation therapy combined with transcranial direct current stimulation for post-stroke aphasia: a single-blind, randomized controlled trial

Novel Technologies Targeting the Rehabilitation of Neurological Disorders

Clinical phenotypes of patients with acute stroke: a secondary analysis

Contact Info

Product

Resources

About