Determining Risk Factors of Epilepsy in Children with Cerebral Palsy: A Retrospective Study

Abstract

were evaluated retrospectively. The diagnosis of CP was based on the definition of motor dysfunction caused by a non-progressive, static lesion in the developing brain (6). The patients were classified according to their gestational age (GA) and birthweight (BW) for GA (7). Newborns who were born prior to 37 weeks and between 37 and 42 weeks were accepted as preterm and term babies, ABS TRACT Aim: The aim of this study is to determine the risk factors of epilepsy development in children with cerebral palsy. Materials and Methods: Data of 234 cerebral palsy patients treated at Ege University Pediatrics Department, Child Neurology Division between January 2008 and December 2015 were evaluated retrospectively. All patients were classified into two groups; Group I: cerebral palsy without epilepsy (n=116) and Group II: cerebral palsy with epilepsy (n=118). The clinical and laboratory findings of the groups were compared to each other, a p value of less than 0.05 was considered as statistically significant. Results: There was no significant difference between the two groups in terms of gender, gestastional age, birth type, birth weight, risk factors for cerebral palsy development (pre-/peri-/postnatal), duration of neonatal intensive care stay and the need for mechanical ventilation (p>0.05). The risk factors of epilepsy were determined as the following; the presence of neonatal convulsions, focal clonic and generalized tonic neonatal seizures, an abnormal baseline rhythm on neonatal electroencephalography (EEG), discharge from neonatal intensive care unit with at least one antiepileptic drug, spastic bilateral (tetraplegic) cerebral palsy, epileptic activity on the sixth month EEG, abnormal cranial magnetic resonance imaging findings, mental retardation, microcephaly and visual problems. Conclusion: Epilepsy is a common problem in children with cerebral palsy. Therefore, cases of cerebral palsy, especially those with the determined risk factors should be closely monitored for epilepsy in order to ensure a timely diagnosis and proper treatment.

Clinical Characteristics and Possible Risk Factors of Epilepsy in Children with Cerebral Palsy: A Tertiary-Center Experience

“…Similar to previous reports, the onset of epilepsy in the current study occurred at a young age (13 months) and more than half of our patients had their first seizures during the first two years of life (11,16). In addition, the median age of seizureonset was earlier in patients with DRE (7 months) than in the controlled epilepsy group (24 months).…”

“…In the current study, there was no significant difference between patients with and without epilepsy in terms of sex, parental consanguinity, and mode of delivery (p>0.050). Similar to our results, Gurkan et al (11) found no significant association between epilepsy development and history of NICU hospitalization. In our study, six of seven patients with a history of neonatal hypoglycemia had epilepsy during follow-up.…”

“…In the present study, 74% of the CP patients had epilepsy. Prevalence of epilepsy in our cohort was higher than in previous reports from different parts of our country, ranging between 50-57% (9)(10)(11)(12). However, a similar rate of epilepsy was reported in the study of Bearden et al (13), the prevalence of epilepsy was also found as high as 77%.…”

Serebral Palsili Çocuklarda Beslenme Alışkanlıkları ve Sorunları: Kesitsel Bir Çalışma

“…Pediatrik SP'liler ile yapılan çalışmalarda epilepsi prevalansı %15 ila %60 arasında değişen oranlarda görülmektedir 16,17 . Ülkemizde Gürkan ve arkadaşlarının çalışmasında ise bu oran %50 olarak bulunmuştur 18 . Çalışmada ise epilepsi oranı %60 saptanmış olup, bu oranın literatüre göre yüksek olduğu görülmektedir.…”

Education on Nutrition and Seizure Control in Children with Cerebral Palsy for “Mitra Ananda” Community Organization in Gunungkidul, Yogyakarta, Indonesia

“…According to the data from the Central Statistics Agency, the percentage of malnutrition in children, especially in Gunung Kidul, was 0.53%, and malnutrition was 6.55% (Badan Pusat Statistik, 2019). Seizures were common in children with Cerebral Palsy with rates varying from 15 percent to 60 percent (Gürkan, et al, 2018) (mostly the mothers of children with Cerebral Palsy), the caregivers wanted to learn and know how to meet the nutrition requirement for children with CP, symptoms that could affect the children's condition, medications advised for managing digestive system disorders. There were limited services related to Cerebral Palsy and there was no pediatrician at the nearest community health center (Puskesmas).…”