Determining rubella immunity in pregnant Alberta women 2009–2012

Lai, Florence; Dover, Douglas C.; Lee, Bonita; Fonseca, Kevin; Solomon, Natalia; Plitt, Sabrina S.; Jaipaul, Joy; Charlton, Carmen

doi:10.1016/j.vaccine.2014.12.022

Cited by 23 publications

(29 citation statements)

References 33 publications

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“…4,16 Latent class modeling of a large prenatal patient population in Canada showed that rubella antibody levels <2-5 IU/ml may more accurately identify those women who lack immunity to infection in universally vaccinated populations. 3 These results are consistent with a recent study that compared 8 different serological assays against the immunoblot (Mikrogen Diagnostik, Neuried, Germany), which uses whole viral lysate to identify rubella specific antibodies. All immunoblot negative samples corresponded to rubella antibody levels <2 IU/ml on the Abbott Architect platform, 17 suggesting that levels >2 IU/ml may indicate immunity to infection.…”

Section: Choosing the Appropriate Test And Assay Cut Offsupporting

confidence: 90%

“…3,4 Likewise, T cell responses have been shown to be long-lived following vaccination. In fact, lymphocyte proliferation was observed in T cells exposed to rubella-specific peptides 14-16 years after a single dose of RA27/3.…”

Section: The Role Of Cell Mediated and Humoral Immune Responses In Vamentioning

confidence: 99%

“…3,4,14 The numbers of acute rubella and congenital rubella syndrome (CRS) cases however have not increased despite waning antibody levels in the population, 4,15,16 highlighting the effectiveness of the current vaccine programs. In the context of herd immunity, the lower antibody levels may therefore be sufficient to protect an individual from rubella infection.…”

Section: Choosing the Appropriate Test And Assay Cut Offmentioning

confidence: 99%

“…Routinely, prenatal screening is performed in the first trimester where total rubella IgG antibody levels are measured. 3 Based on the 1992 NCCLS Rubella Subcommittee recommendations, women who have antibodies >10 IU/ml should be considered immune, while those with antibody levels 10 IU/ml should be considered susceptible to infection. This generates questions from the laboratory and physicians alike for women who are only slightly below the cutoff.…”

Section: Effect Of Laboratory Testing On Public Health and Health Carmentioning

confidence: 99%

See 3 more Smart Citations

How to determine protective immunity in the post-vaccine era

Charlton

Lai

Dover

2016

Human Vaccines & Immunotherapeutics

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Section: Choosing the Appropriate Test And Assay Cut Offsupporting

confidence: 90%

Section: The Role Of Cell Mediated and Humoral Immune Responses In Vamentioning

confidence: 99%

Section: Choosing the Appropriate Test And Assay Cut Offmentioning

confidence: 99%

Section: Effect Of Laboratory Testing On Public Health and Health Carmentioning

confidence: 99%

See 2 more Smart Citations

How to determine protective immunity in the post-vaccine era

Charlton

Lai

Dover

2016

Human Vaccines & Immunotherapeutics

Self Cite

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“…16 These strategies have been introduced into regular obstetrics care and have shown good performance in the United Kingdom, Canada, Japan, and other countries. [17][18][19] Therefore, to eliminate rubella infection, the postpartum immunization should be launched and vaccination should be provided to the susceptible women, either native or immigrant, before they are discharged from hospitals. 20 In Taiwan, almost all women have prenatal checkups.…”

Section: Discussionmentioning

confidence: 99%

Rubella Immunity in Pregnant Native Taiwanese and Immigrants from Asian Countries

Zen

Shih

Kung

et al. 2017

The American Society of Tropical Medicine and Hygiene

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Abstract. Vaccination is considered the most effective method to prevent rubella spread and congenital rubella syndrome (CRS). The aim of the present study was to investigate the rubella immunity among native and immigrant pregnant women in Taiwan. From 2000 to 2014, a total of 16,879 pregnant women who received routine prenatal examinations were recruited in this study. The rubella IgG antibodies were assayed using a microparticle enzyme immunoassay or chemiluminescent microparticle immunoassay. Subjects were categorized by nationality and subcategorized by specific periods of time for comparison. The rubella susceptibility was 12.7% in total, 11.1% in Taiwanese and 20.3% in immigrant population from 2000 to 2014. Among the immigrant women, those from Vietnam had the highest susceptibility (22.3%) and those from Thailand had the lowest susceptibility (3.8%). The immigrant women from Vietnam and China showed a significantly higher susceptibility compared with the native Taiwanese women in which the odds ratio was 2.30 (95% confidence interval [CI]: 2.04-2.60), 1.96 (95% CI: 1.59-2.41), respectively ( P < 0.001). It meant that immigrants from Vietnam and China had a higher likelihood of rubella susceptibility and related CRS sequela than native women.

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Screening for potential susceptibility to rubella in an antenatal population: A multivariate analysis

Snell

Smith

Chaytor

et al. 2017

Journal of Medical Virology

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Rubella causes disease in the fetus. Immunity to rubella is therefore, routinely screened in pregnant women. In this retrospective observational study, we assessed the levels of potential susceptibility to rubella in the population of a north London antenatal clinic. Risk factors for potential susceptibility to rubella and changes in potential susceptibility to rubella over time were studied. Almost all women were screened for potential susceptibility to rubella (99.8%). The majority were predicted to be immune (96.8%). Women booking in later years within the study period showed higher levels of potential susceptibility to rubella. Booking during each subsequent year in the study gave women an odds ratio of 0.91 (CI:0.84, 0.98, P = 0.009) of being predicted to have immunity against rubella. Age was associated with predicted immunity to rubella, with a 5.1% (CI:3.3%, 6.9%, P < 0.001) increased likelihood for every year older. Previous pregnancy was predictive of immunity against rubella with an odds ratio of 1.41 (CI 1.21, 1.61, P = 0.001). Those from a non-white ethnicity were less likely to have antibodies predictive of immunity (OR: 0.730, CI: 0.581, 0.879 P < 0.001). Country of birth was associated with differences in potential susceptibility, with those being born outside of the British Isles having an odds ratio for predicted immunity of 0.63 (CI:0.35,0.91, P = 0.001). Being born in a high-risk country for rubella non-immunity was also a risk factor, giving an odds ratio of predicted immunity to rubella of 0.55 (CI:0.32, 0.77, P < 0.001).

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Determining rubella immunity in pregnant Alberta women 2009–2012

Cited by 23 publications

References 33 publications

How to determine protective immunity in the post-vaccine era

How to determine protective immunity in the post-vaccine era

Rubella Immunity in Pregnant Native Taiwanese and Immigrants from Asian Countries

Screening for potential susceptibility to rubella in an antenatal population: A multivariate analysis

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