Determining Serum Levels of IL-10 and IL-17 in Patients with Low Back Pain Caused by Lumbar Disc Degeneration

Banimostafavi, Elham Sadat; Fakhar, Mahdi; Abediankenari, Saeid; Alizadeh‐Navaei, Reza; Mehdipour, Khashayar; Omrani‐Nava, Versa; Majidi, Hadi

doi:10.2174/1871526520666200820093924

Cited by 10 publications

(10 citation statements)

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“…Evidence-Based Complementary and Alternative Medicine impaired regulation of insulin signaling might promote the development of and pain sensation with diabetic neuropathy, which can be alleviated by its functional restoration [266][267][268][269]. e interleukin-(IL-) 17 pathway plays a crucial role in cellular mechanisms of pain pathogenesis and maintenance in various diseases including multiple sclerosis, prostatitis, intervertebral disk degeneration, femoral head osteonecrosis, and neuropathy; its inhibition might block the generation and persistence of pain [270][271][272][273][274][275][276][277][278][279][280][281][282]. Arachidonic acid metabolism is associated with the generation and secretion of diverse biomolecular substances Evidence-Based Complementary and Alternative Medicine responsible for the induction of inflammation and pain, and it is mainly involved in the mechanisms of action of NSAIDs [283][284][285][286][287][288].…”

Section: Functional Enrichment Investigation Of Jakyak-gamchomentioning

confidence: 99%

An Investigation of the Molecular Mechanisms Underlying the Analgesic Effect of Jakyak‐Gamcho Decoction: A Network Pharmacology Study

Lee¹,

Kang

Park³

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Herbal drugs have drawn substantial interest as effective analgesic agents; however, their therapeutic mechanisms remain to be fully understood. To address this question, we performed a network pharmacology study to explore the system-level mechanisms that underlie the analgesic activity of Jakyak-Gamcho decoction (JGd; Shaoyao-Gancao-Tang in Chinese and Shakuyaku-Kanzo-To in Japanese), an herbal prescription consisting of Paeonia lactiflora Pallas and Glycyrrhiza uralensis Fischer. Based on comprehensive information regarding the pharmacological and chemical properties of the herbal constituents of JGd, we identified 57 active chemical compounds and their 70 pain-associated targets. The JGd targets were determined to be involved in the regulation of diverse biological activities as follows: calcium- and cytokine-mediated signalings, calcium ion concentration and homeostasis, cellular behaviors of muscle and neuronal cells, inflammatory response, and response to chemical, cytokine, drug, and oxidative stress. The targets were further enriched in various pain-associated signalings, including the PI3K-Akt, estrogen, ErbB, neurotrophin, neuroactive ligand-receptor interaction, HIF-1, serotonergic synapse, JAK-STAT, and cAMP pathways. Thus, these data provide a systematic basis to understand the molecular mechanisms underlying the analgesic activity of herbal drugs.

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Section: Functional Enrichment Investigation Of Jakyak-gamchomentioning

confidence: 99%

An Investigation of the Molecular Mechanisms Underlying the Analgesic Effect of Jakyak‐Gamcho Decoction: A Network Pharmacology Study

Lee¹,

Kang

Park³

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…The innate immune system can further secrete IL-17 ( 109 ). IL-17 is associated with inflammation, and increasing evidence has shown that IL-17 is involved in the occurrence and progression of IVDD ( 110 – 112 ). There is no IL-17 in normal AF and NP, and elevations of IL-17 can be detected in degenerative structures ( 113 ).…”

Section: Regulation Of the Inflammatory Microenvironmentmentioning

confidence: 99%

Biomaterials delivery strategies to repair degenerated intervertebral discs by regulating the inflammatory microenvironment

et al. 2023

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Intervertebral disc degeneration (IVDD) is one of the leading causes of lower back pain. Although IVDD cannot directly cause death, it can cause pain, psychological burdens, and economic burdens to patients. Current conservative treatments for IVDD can relieve pain but cannot reverse the disease. Patients who cannot tolerate pain usually resort to a strategy of surgical resection of the degenerated disc. However, the surgical removal of IVDD can affect the stability of adjacent discs. Furthermore, the probability of the reherniation of the intervertebral disc (IVD) after surgery is as high as 21.2%. Strategies based on tissue engineering to deliver stem cells for the regeneration of nucleus purposes (NP) and annulus fibrosus (AF) have been extensively studied. The developed biomaterials not only locally withstand the pressure of the IVD but also lay the foundation for the survival of stem cells. However, the structure of IVDs does not provide sufficient nutrients for delivered stem cells. The role of immune mechanisms in IVDD has recently become clear. In IVDD, the IVD that was originally in immune privilege prevents the attack of immune cells (mainly effector T cells and macrophages) and aggravates the disease. Immune regulatory and inflammatory factors released by effector T cells, macrophages, and the IVD further aggravate IVDD. Reversing IVDD by regulating the inflammatory microenvironment is a potential approach for the treatment of the disease. However, the biological factors modulating the inflammatory microenvironment easily degrade in vivo. It makes it possible for different biomaterials to modulate the inflammatory microenvironment to repair IVDD. In this review, we have discussed the structures of IVDs and the immune mechanisms underlying IVDD. We have described the immune mechanisms elicited by different biological factors, including tumor necrosis factors, interleukins, transforming growth factors, hypoxia-inducible factors, and reactive oxygen species in IVDs. Finally, we have discussed the biomaterials used to modulate the inflammatory microenvironment to repair IVDD and their development.

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“… 112 Moreover, serum levels of IL‐10 are reported to be lower in LBP patients than controls. 113 Zhou et al 114 demonstrated that IL‐10 led to a reduction in pain sensitivity in the spinal dorsal horn induced by formalin injection. Following injury to the sciatic nerve and DRG in a mouse model, the expression level of IL‐10 was increased.…”

Section: Immune Cytokines Involved In Ivd Degenera...mentioning

confidence: 99%

“…IL‐10 treatment suppresses the expression of IL‐1β and TNF‐α as a consequence of the impeded development of inflammatory responses 112 . Moreover, serum levels of IL‐10 are reported to be lower in LBP patients than controls 113 . Zhou et al 114 demonstrated that IL‐10 led to a reduction in pain sensitivity in the spinal dorsal horn induced by formalin injection.…”

Section: Immune Cytokines Involved In Ivd Degeneration/herniationmentioning

confidence: 99%

The involvement of immune system in intervertebral disc herniation and degeneration

Lyu

Wang

et al. 2022

JOR Spine

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Intervertebral disc (IVD) herniation and degeneration contributes significantly to low back pain (LBP), of which the molecular pathogenesis is not fully understood. Disc herniation may cause LBP and radicular pain, but not all LBP patients have disc herniation. Degenerated discs could be the source of pain, but not all degenerated discs are symptomatic. We previously found that disc degeneration and herniation accompanied by inflammation. We further found that anti-inflammatory molecules blocked immune responses, alleviated IVD degeneration and pain. Based on our recent findings and the work of others, we hypothesize that immune system may play a prominent role in the production of disc herniation or disc degeneration associated pain. While the nucleus pulposus (NP) is an immune-privileged organ, the damage of the physical barrier between NP and systemic circulation, or the innervation and vascularization of the degenerated NP, on one hand exposes NP as a foreign antigen to immune system, and on the other hand presents compression on the nerve root or dorsal root ganglion (DRG), which both elicit immune responses induced by immune cells and their mediators. The inflammation can remain for a long time at remote distance, with various types of cytokines and immune cells involved in this pain-inducing process. In this review, we aim to revisit the autoimmunity of the NP, immune cell infiltration after break of physical barrier, the inflammatory activities in the DRG and the generation of pain. We also summarize the involvement of immune system, including immune cells and cytokines, in degenerated or herniated IVDs and affected DRG.

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Determining Serum Levels of IL-10 and IL-17 in Patients with Low Back Pain Caused by Lumbar Disc Degeneration

Cited by 10 publications

References 0 publications

An Investigation of the Molecular Mechanisms Underlying the Analgesic Effect of Jakyak‐Gamcho Decoction: A Network Pharmacology Study

An Investigation of the Molecular Mechanisms Underlying the Analgesic Effect of Jakyak‐Gamcho Decoction: A Network Pharmacology Study

Biomaterials delivery strategies to repair degenerated intervertebral discs by regulating the inflammatory microenvironment

The involvement of immune system in intervertebral disc herniation and degeneration

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