To study the effective stone clearance rate, to analyze and study the intra and post-operative complications and the morbidity in terms of hospital stay. MATERIALS AND METHODS: The present study has been conducted in the Department of Urology, Gandhi Hospital, and Hyderabad from November 2012 to December 2014. RESULTS: Total 42 cases were included in supracostal group, in which mid calyceal puncture done in 5 (11.9%) cases, upper calyceal puncture done in 37(88.1%) cases. Post-operative x-ray chest on day one normal in 39(92.85%) cases and 3(7.15%) cases developed hydrothorax, post-operative pain assessment: visual analogue score on average-6.5, post-operative x-ray KUB on day two showed insignificant calculi in 2(4.76%) cases and significant calculi in 3(7.1%) cases. Ancillary procedure: needed for 3(7.1%) cases with significant calculi, one case (2.4%) required relook PCNL and for two cases (4.7%) ESWL was done and blood transfusion required for 3 cases (7.1%). Finally stone clearance rate was 88.9%. CONCLUSIONS: Supracostal PCNL is a safe procedure with acceptable morbidity. When the puncture site is well planned, keeping it on or lateral to posterior axillary line and performed during expiration, would minimize thoracic complications. Supra costal PCNL has high rate of stone clearance (more than 90%) especially when the stone is complex, burden is in upper pole and stone is of stag horn type. The need for ancillary procedures for complete stone clearance is less. The requirement of multiple tracts and their attendant complications are less with supracostal PCNL. It can be done safely in pediatric as well as elderly population.