Determining Surface Energy of Porous Substrates by Spray Ionization

Damon, Deidre E.; Maher, Yosef S.; Allen, Danyelle M; Baker, Jill; Chang, Boyce S.; Maher, Simon; Thuo, Martin M.; Badu‐Tawiah, Abraham K.

doi:10.1021/acs.langmuir.9b02419

Cited by 7 publications

(7 citation statements)

References 38 publications

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“…In contrast, no significant differences in signal intensities of the antibiotics were observed between the papers exposed to the silanization reagent for 2 and 4 h and the normal hydrophilic paper. The enhancement of signal intensity using paper with a specific exposure time (3 h) is consistent with the results reported by Damon et al (2019). They found that the signal intensity in PSI is maximized when the surface energy of the substrate matches the surface tension of the wetting solvent.…”

Section: Effect Of the Properties Of The Paper Surface On The Spray Modesupporting

confidence: 89%

“…However, the Taylor cone formation is hindered at voltages lower than the onset voltage in PSI. Damon et al suggested that electrostatic spray ionization can occur on a hydrophobic paper in PSI (Damon et al, 2019). For a hydrophobic paper, capacitive charging occurs in a solvent droplet on the paper tip, inducing electrostatic force along the axis connecting the paper tip and the MS orifice.…”

Section: Effect Of the Properties Of The Paper Surface On The Spray Modementioning

confidence: 99%

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Characterization of Spray Modes and Factors Affecting the Ionization Efficiency of Paper Spray Ionization

2022

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In this study, we systematically evaluated the factors affecting the ionization efficiency of paper spray ionization (PSI), such as electric field, solvent supply rate, and paper thickness and hydrophobicity. The observed paper spray plume was classified into three modes: single cone-jet, multi-jet, and rim-jet modes. With the increase in the spraying voltage, the spray plume appeared in order of single cone-jet, multi-jet, and rim-jet modes. The rim-jet mode exhibited the lowest standard deviation and high ionization efficiency among the three spray modes. The main parameter determining the spray mode was the charge density of the droplets generated by paper spray, which depends on the electric field and solvent supply rate. A thicker paper reduced the electric repulsion between the jets and lowered the threshold voltage to reach the rim-jet mode. Lowering the solvent supply rate caused mode transitions from the single cone-jet to the rim-jet, possibly due to the increased droplet charge density. The hydrophobic modification on a paper substrate led to a different ionization mechanism or electrostatic spray ionization at low applied voltages.

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Section: Effect Of the Properties Of The Paper Surface On The Spray Modesupporting

confidence: 89%

Section: Effect Of the Properties Of The Paper Surface On The Spray Modementioning

confidence: 99%

Characterization of Spray Modes and Factors Affecting the Ionization Efficiency of Paper Spray Ionization

2022

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“…polarity, volatility, surface tension, etc.) play a significant role in the spray process of PS 63 and many similarities are observed when compared with conventional electrospray ionization 5 . Typically, the spray solvent composition is adjusted, as well as the sample solvent (where possible), to optimize the spray conditions for the analysis at hand 64,65 .…”

Section: Direct Analysis and Solvent Optimization Of Free Steroids Inmentioning

confidence: 99%

Analysis of non-conjugated steroids in water using paper spray mass spectrometry

Jjunju

Damon

Romero-Perez

et al. 2020

Sci Rep

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A novel strategy for the direct analysis of non-conjugated steroids in water using paper spray mass spectrometry (PS-MS) has been developed. PS-MS was used in the identification and quantification of non-conjugated (free) steroids in fish tank water samples. Data shown herein indicates that individual amounts of free steroids can be detected in aqua as low as; 0.17 ng/µL, 0.039 ng/µL, 0.43 ng/µL, 0.0076 ng/µL for aldosterone, corticosterone, cortisol, and β-estrone, respectively, and with an average relative standard deviation of ca. < 10% in the positive ion mode using PS-MS/MS. Direct detection of free steroids in a raw water mixture, from aquaculture, without prior sample preparation is demonstrated. The presence of free steroids released in fish water samples was confirmed via tandem mass spectrometry using collision-induced dissociation. this approach shows promise for rapid and direct water quality monitoring to provide a holistic assessment of non-conjugated steroids in aqua.

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“…Paper spray ionization–tandem mass spectrometry (PSI–MS/MS) for direct analysis of modified DBS enables rapid quantification of endogenous and xenobiotic compounds from whole blood samples 16 – 23 . The analyte solution is spotted onto a small triangular paper followed by the application of spray solvent and a high electric potential (> 3 kV), to instigate electrospray-like ionization 24 – 29 . Hence, this method integrates three main analytical procedures into one step: sample collection, analyte extraction, and analyte ionization, without the need for the time-consuming punching and extraction procedures of DBS.…”

Section: Introductionmentioning

confidence: 99%

Assessment of creatinine concentration in whole blood spheroids using paper spray ionization–tandem mass spectrometry

Sham

Badu‐Tawiah

McWilliam

et al. 2022

Sci Rep

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Accurate quantification of blood creatinine is important to estimate the glomerular filtration rate. Existing techniques using liquid chromatography tandem mass spectrometry (LC–MS/MS) have a high accuracy and eliminate most interferences encountered in routine enzymatic and Jaffé methods. However, they require laborious and time-consuming sample treatment and data acquisition. The aim of this study is to develop a fast and simple method to enable a direct analysis of whole blood creatinine with performance measures that are comparable to conventional LC–MS/MS. 5μL whole blood is formed as a three-dimensional spheroid on hydrophobic silanized paper substrates which then undergoes paper-spray ionization—tandem mass spectrometry (PSI–MS/MS). The method is validated using real human samples and compared with LC–MS/MS. PSI–MS/MS whole blood analysis exhibited a lower limit of quantification of 2.5 μg/mL, precision ≤ 6.3%, recovery in the range of 88–94% and excellent linearity (R2 > 0.99; 2.5—20 μg/mL) covering the normal range for creatinine levels. Creatinine levels were comparable to those measured by LC–MS/MS with small deviations of less than 0.3 μg/mL. This simple, fast and accurate microsampling technique for direct analysis of creatinine from whole blood shows promise for routine clinical screening and monitoring. This approach can be readily extended for other analytes of interest and, due to inherent advantages relating to cost, storability, speed, and simplicity, it can be especially advantageous for use in resource-limited settings.

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Determining Surface Energy of Porous Substrates by Spray Ionization

Cited by 7 publications

References 38 publications

Characterization of Spray Modes and Factors Affecting the Ionization Efficiency of Paper Spray Ionization

Characterization of Spray Modes and Factors Affecting the Ionization Efficiency of Paper Spray Ionization

Analysis of non-conjugated steroids in water using paper spray mass spectrometry

Assessment of creatinine concentration in whole blood spheroids using paper spray ionization–tandem mass spectrometry

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