Determining the best graft‐sealant combination for skull base repair using a soft tissue in vitro porcine model

Fandiño, Marcela; Macdonald, Kristian I.; Singh, Devin; Whyne, Cari; Witterick, Ian J.

doi:10.1002/alr.21085

Cited by 20 publications

(17 citation statements)

References 14 publications

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“…Multiple additional papers address a variety of other topics and will be presented here in descending order of frequency (Table 5) for the use of fibrin sealant in the form of platelet-rich (PRP) or platelet-poor plasma (PPP) [203–213], hepatic surgery [214–222], neurosurgery [223–233], joint replacement orthopedic surgery [234–241], head and neck surgery [242–248], vascular surgery [61, 249–252], gastrointestinal surgery [253–258], gastroesophageal surgery [259–262], other orthopedic surgery [263–266], renal surgery [267–271], cardiac surgery [272–274], dental surgery [275–277], hemophilia [278–280], obstetrical and gynecological surgery [281–283], pancreatic surgery [284–286], transsphenoidal surgery [287–289], bariatric surgery [290, 291], drug delivery [292, 293], endoscopic polypectomy [294, 295], plastic surgery [83, 296], skull base reconstruction [297, 298], complications [299], trauma [300], and urology [301]. …”

Section: Less Frequently Published Clinical Applications Of Fibrinmentioning

confidence: 99%

“…The best in-vitro ratio was found using a high fibrinogen concentration fibrin sealant with a 5 : 1 ration of initial fibrinogen (i.e., 80 mg/mL × 5) and the usual thrombin concentration (250 IU/mL) to maximize adhesion strength [297] while the best in-vitro graft and sealant combination was found with fibrin sealant combined with pericranium ( P < 0.0001) [298]. In the latter study, the difference between fibrin sealant and PEG polymer hydrogel with trilysine amine was not significant ( P = 0.22).…”

Section: Less Frequently Published Clinical Applications Of Fibrinmentioning

confidence: 99%

See 1 more Smart Citation

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

2014

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Background. Fibrin sealant became the first modern era material approved as a hemostat in the United States in 1998. It is the only agent presently approved as a hemostat, sealant, and adhesive by the Food and Drug Administration (FDA). The product is now supplied as patches in addition to the original liquid formulations. Both laboratory and clinical uses of fibrin sealant continue to grow. The new literature on this material also continues to proliferate rapidly (approximately 200 papers/year). Methods. An overview of current fibrin sealant products and their approved uses and a comprehensive PubMed based review of the recent literature (February 2012, through March 2013) on the laboratory and clinical use of fibrin sealant are provided. Product information is organized into sections based on a classification system for commercially available materials. Publications are presented in sections based on both laboratory research and clinical topics are listed in order of decreasing frequency. Results. Fibrin sealant remains useful hemostat, sealant, and adhesive. New formulations and applications continue to be developed. Conclusions. This agent remains clinically important with the recent introduction of new commercially available products. Fibrin sealant has multiple new uses that should result in further improvements in patient care.

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Section: Less Frequently Published Clinical Applications Of Fibrinmentioning

confidence: 99%

Section: Less Frequently Published Clinical Applications Of Fibrinmentioning

confidence: 99%

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

2014

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“…The authors did not find any significant difference in the recurrence of the leak between the two groups [33]. In vitro (N = 2) studies comparing various endoscopic repair strategies found that the burst pressure was significantly increased when a fibrin sealant was used than in the control group [34]. In a randomized animal study, [14] leaks were repaired with or without fibrin glue, and then the pericranial graft adhesion was later assessed.…”

Section: Discussionmentioning

confidence: 98%

Late Post-Traumatic Cerebrospinal Rhinorrhoea

Kouakou¹,

Kouitcheu²,

Mbende³

et al. 2017

OJMN

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Cerebrospinal fluid (CSF) rhinorrhoea results from anatomical breach between the subarachnoid space and air sinus cavities of the skull base and traumatic CSF rhinorrhoea accounts for 80% -90% of all cases of CSF leaks. We sought to report the case of a 16-year-old patient with a history of head injury following a fall from a tree, who developed a post-traumatic CSF rhinorrhoea after an onset of meningitis. The patient sustained a fall from a 6-meter tree in 2008, and was reviewed by our neurosurgical team in February 2016 for a 1-month history of progressive headaches associated with fever, asthenia and left CSF rhinorrhoea. Clinical examination revealed frank meningism and abundant CSF leak from the left nostril. CT scanning showed fractures of the left frontal bone and sinus wall associated with a massive pneumocephalus. The patient benefited from surgical repair of the tear and post-operative lumbar punctures at day 15. The patient's guardian was informed that non-identifiable information from the case would be submitted for publication and he provided consent.

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“…12 Fibrin-based sealant, on the other hand, has been shown to significantly reduce the incidence of postoperative CSF leak 44 and is associated with enhanced biomechanical strength of skull base repair. 45 …”

Section: Discussionmentioning

confidence: 99%

One-Piece Modified Gasket Seal Technique

Wessell¹,

Singh²,

Litvack³

2013

J Neurol Surg B

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Determining the best graft‐sealant combination for skull base repair using a soft tissue in vitro porcine model

Abstract: In this model, the strongest type of repair (pressure 6 times higher than normal intracranial pressure) was the combination of Tisseel(®)-pericranium. Our data will help guide surgeons who repair SB defects to choose the best graft and sealant.

Cited by 20 publications

References 14 publications

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

Late Post-Traumatic Cerebrospinal Rhinorrhoea

One-Piece Modified Gasket Seal Technique

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