Determining the effect of radiotherapy on the optical properties of white matter of the brain using cross-polarization OCT

Achkasova, Ksenia; Yashin, Konstantin; Moiseev, Alexander A.; Kiseleva, Elena B.; Bederina, Evgeniya; Medyanik, Igor; Gladkova, Natalia D.

doi:10.1117/12.2607025

Cited by 1 publication

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“…As a result, the formation of morphological changes in white matter, especially changes in the myelinated fibers integrity and packing, are reflected in its scattering properties what can be detected by OCT. In our previously published work, we demonstrated that OCT is capable of detecting damage to peritumoral white matter resulting from tumor growth [22]. Consequently, it has been suggested that this technology could be used to visualize structural changes in white matter due to radiation therapy for brain neoplasms.…”

Section: Discussionmentioning

confidence: 96%

“…In particular, the possibility of obtaining high-quality images of a number of nervous structures of the central and peripheral nervous system, up to the visualization of individual myelinated fibers, has been shown [21]. In addition, in our previous study it has been demonstrated that OCT can detect areas of white matter damage characterized by destruction of myelinated fibers resulting from infiltrative tumor growth, which can be used to find the resection margin of gliomas [22].…”

Section: Introductionmentioning

confidence: 99%

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Detection of acute and early‐delayed radiation‐induced changes in the white matter of the rat brain based on numerical processing of optical coherence tomography data

Achkasova,

Kukhnina,

Moiseev

et al. 2024

Journal of Biophotonics

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Detection of radiation‐induced changes of the brain white matter is important for brain neoplasms repeated surgery. We investigated the influence of irradiation on the scattering properties of the white matter using optical coherence tomography (OCT). Healthy Wistar rats undergone the irradiation of the brain right hemisphere. At seven time points from the irradiation procedure (2–14 weeks), an ex vivo OCT study was performed with subsequent calculation of attenuation coefficient values in the corpus callosum followed by immunohistochemical analysis. As a result, we discovered acute and early‐delayed changes characterized by the edema of different severity, accompanied by a statistically significant decrease in attenuation coefficient values. In particular, these changes were found at 2 weeks after irradiation in the irradiated hemisphere, while at 6‐ and 12‐week time points they affected both irradiated and contralateral hemisphere. Thus, radiation‐induced changes occurring in white matter during the first 3 months after irradiation can be detected by OCT.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%