Determining the Incidence of Horseshoe Kidney From Radiographic Data at a Single Institution

Weizer, Alon Z.; Silverstein, Ari D.; Auge, Brian K.; Delvecchio, Fernando C.; Raj, Ganesh V.; Albala, David; Leder, Richard A.; Preminger, Glenn M.

doi:10.1097/01.ju.0000092537.96414.4a

Cited by 135 publications

(99 citation statements)

References 19 publications

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“…In this study, we examined the cause of the phenotypes displayed by the Foxd1 -/-kidney, including pelvic kidneys and disorganization of the ureteric and nephrogenic compartments. Indeed, the presence of fused kidneys in the Foxd1 -/-embryo is of particular interest because of the prevalent urological condition this represents in humans -about one in 400-600 live births (Nation, 1945;Weizer et al, 2003). We propose a novel explanation for kidney fusion: defects in the stromal cell population result in the inability of the kidneys to detach from the body wall or separate from the midline.…”

Section: Loss Of Foxd1 Expression Results In Fused Kidneys Due To Capmentioning

confidence: 99%

Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development

et al. 2005

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Development of the metanephric kidney involves the establishment of discrete zones of induction and differentiation that are crucial to the future radial patterning of the organ. Genetic deletion of the forkhead transcription factor, Foxd1, results in striking renal abnormalities, including the loss of these discrete zones and pelvic fused kidneys. We have investigated the molecular and cellular basis of the kidney phenotypes displayed by Foxd1-null embryos and report here that they are likely to be caused by a failure in the correct formation of the renal capsule. Unlike the single layer of Foxd1-positive stroma that comprises the normal renal capsule, the mutant capsule contains heterogeneous layers of cells, including Bmp4-expressing cells, which induce ectopic phospho-Smad1 signaling in nephron progenitors. This missignaling disrupts their early patterning,which, in turn, causes mispatterning of the ureteric tree, while delaying and disorganizing nephrogenesis. In addition, the defects in capsule formation prevent the kidneys from detaching from the body wall, thus explaining their fusion and pelvic location. For the first time, functions have been ascribed to the renal capsule that include delineation of the organ and acting as a barrier to inappropriate exogenous signals, while providing a source of endogenous signals that are crucial to the establishment of the correct zones of induction and differentiation.

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Section: Loss Of Foxd1 Expression Results In Fused Kidneys Due To Capmentioning

confidence: 99%

Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development

et al. 2005

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“…Weizer et al [43] had a SFR of 75% in patients with horseshoe kidney with a kidney stone smaller than 2 cm, while Molimard et al [44] reported that SFR was 53% after first session and added that this SFR rose to 88% after an average of 1.5 procedures in 17 patients. Atis et al [45] found a SFR of 70% at postoperative 1 st month in 20 horseshoe kidneys, while 2 of the 6 patients with residual stone became stone-free after SWL.…”

Section: Rirs In Horseshoe Kidneysmentioning

confidence: 99%

Retrograde intrarenal surgery for renal stones - Part 2

Kılıç

Akand

2017

Turkish Journal of Urology

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Retrograde intrarenal surgery (RIRS) has become an effective and safe treatment modality in the management of urinary system stone disease. Recent developments and innovations in the flexible ureterorenoscope and auxiliary equipment have made this procedure easier and more effective with increased success rates. RIRS can be used as a primary treatment in patients with renal stones smaller than 2 cm, prior unsuccessful shock wave lithotripsy, infundibular stenosis, renoureteral malformation, skeletal-muscular deformity, bleeding diathesis and obese patients. In the second part of this detailed review for RIRS, effect of stone composition on success rate, preoperative assessment of stone-free rate, the cost of this modality, education for RIRS, fluoroscopy use, the current role of RIRS in the treatment of various urolithiasis types and special conditions, and combined treatment methods are discussed with up-to-date literature.

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“…Some of these defects (e.g. horseshoe kidney, unilateral renal agenesis) do not require surgical intervention and may not even be diagnosed (Weizer, 2002), while others may require extensive reconstructive surgery. The latter include bladder reconstruction for persistent cloaca, organ transplantation for cystic kidney disease and renal dysgenesis, removal of streak gonads and Müllerian duct remnants for XY pseudohermaphroditism and penile reconstruction for hypospadias and diphallia (Gyftopoulos, 2002;Warne, 2002).…”

Section: Development and Disorders Of The Genitourinary Tractmentioning

confidence: 99%

A high-resolution anatomical ontology of the developing murine genitourinary tract

Little

Brennan

Georgas

et al. 2007

Gene Expression Patterns

131

111

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Cataloguing gene expression during development of the genitourinary tract will increase our understanding not only of this process but also of congenital defects and disease affecting this organ system. We have developed a high-resolution ontology with which to describe the subcompartments of the developing murine genitourinary tract. This ontology incorporates what can be defined histologically and begins to encompass other structures and cell types already identified at the molecular level. The ontology is being used to annotate in situ hybridisation data generated as part of the Genitourinary Development Molecular Anatomy Project (GUDMAP), a publicly available data resource on gene and protein expression during genitourinary development. The GUDMAP ontology encompasses Theiler stage (TS) 17 to 27 of development as well as the sexually mature adult. It has been written as a partonomic, text-based, hierarchical ontology that, for the

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Determining the Incidence of Horseshoe Kidney From Radiographic Data at a Single Institution

Cited by 135 publications

References 19 publications

Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development

Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development

Retrograde intrarenal surgery for renal stones - Part 2

A high-resolution anatomical ontology of the developing murine genitourinary tract

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