Determining the mechanism of interaction between molecules of porphyrin and fullerene and gold nanoparticles, based on luminescence spectroscopy data

Evdokimova, Marina; Konev, Alexander S.; Povolotckaia, Anastasia; Kolesnikov, Ilya E.; Kazakova, A. V.; Povolotskiy, Alexey V.

doi:10.3103/s1062873817120103

Cited by 3 publications

(2 citation statements)

References 18 publications

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“… 54 Evdokimova et al found that porphyrin with four bromine groups has a stronger affinity for the surfaces of gold nanoparticles than that of porphyrin without functional groups. 55 Zhang et al suggested that porphyrin monomers are first adsorbed on the gold nanosurfaces through the coordination interaction between gold and pyrrolic nitrogen atoms, followed by the formation of linear or necklace chain assemblies of the gold nanospheres via the π–π stacking interaction between porphyrin monomers. 35 Kanehara et al showed that all of the ring nitrogen atoms of porphyrin are involved in binding to the nanosurface and aligned the porphyrin rings quite parallel to the gold nanosurface.…”

Section: Resultsmentioning

confidence: 99%

“…Nada et al reported that π-conjugated phthalocyanine rings can serve as stabilizing ligands for gold nanoparticles through van der Waals interaction between parallel-adsorbed phthalocyanine ligands and the gold nanoparticle surface . Evdokimova et al found that porphyrin with four bromine groups has a stronger affinity for the surfaces of gold nanoparticles than that of porphyrin without functional groups . Zhang et al suggested that porphyrin monomers are first adsorbed on the gold nanosurfaces through the coordination interaction between gold and pyrrolic nitrogen atoms, followed by the formation of linear or necklace chain assemblies of the gold nanospheres via the π–π stacking interaction between porphyrin monomers .…”

Section: Resultsmentioning

confidence: 99%

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Porphyrin–Gold Nanomaterial for Efficient Drug Delivery to Cancerous Cells

et al. 2018

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With an aim to overcome multidrug resistance (MDR), nontargeted delivery, and drug toxicity, we developed a new nanochemotherapeutic system with tetrasodium salt of meso-tetrakis(4-sulfonatophenyl)porphyrin (TPPS) armored on gold nanoparticles (TPPS-AuNPs). The nanocarrier is able to be selectively internalized within tumor cells than in normal cells followed by endocytosis and therefore delivers the antitumor drug doxorubicin (DOX) particularly to the nucleus of diseased cells. The embedment of TPPS on the gold nanosurface provides excellent stability and biocompatibility to the nanoparticles. Porphyrin interacts with the gold nanosurface through the coordination interaction between gold and pyrrolic nitrogen atoms of the porphyrin and forms a strong association complex. DOX-loaded nanocomposite (DOX@TPPS-AuNPs) demonstrated enhanced cellular uptake with significantly reduced drug efflux in MDR brain cancer cells, thereby increasing the retention time of the drug within tumor cells. It exhibited about 9 times greater potency for cellular apoptosis via triggered release commenced by acidic pH. DOX has been successfully loaded on the porphyrin-modified gold nanosurface noncovalently with high encapsulation efficacy (∼90%) and tightly associated under normal physiological conditions but capable of releasing ∼81% of drug in a low-pH environment. Subsequently, DOX-loaded TPPS-AuNPs exhibited higher inhibition of cellular metastasis, invasion, and angiogenesis, suggesting that TPPS-modified AuNPs could improve the therapeutic efficacy of the drug molecule. Unlike free DOX, drug-loaded TPPS-AuNPs did not show toxicity toward normal cells. Therefore, higher drug encapsulation efficacy with selective targeting potential and acidic-pH-mediated intracellular release of DOX at the nucleus make TPPS-AuNPs a “magic bullet” for implication in nanomedicine.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Porphyrin–Gold Nanomaterial for Efficient Drug Delivery to Cancerous Cells

et al. 2018

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Fluorescent Ratiometric Thermometers Based on Dyads of Tetraphenylporphyrin and Zinc Metalated Tetraphenylporphyrin

Povolotskiy,

Smirnova,

Soldatova

et al. 2023

Bull. Russ. Acad. Sci. Phys.

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Fluorescent ratiometric thermometers based on dyads of tetraphenyl porphyrin and zinc-metallated tetraphenyl porphyrin

Povolotskiy,

Smirnova,

Soldatova

et al. 2023

Izvestiâ Akademii nauk SSSR. Seriâ fizičeskaâ

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Porphyrins and their derivatives are known for their ability to emit two fluorescence bands. We presented the results of the investigation of the intensity ratio dependence for these bands on temperature in the range of 25–75°C for non-metaled and metal-plated with zinc porphyrins, as well as porphyrin dyads in solutions of 1,2-dichloroethane. A comparative analysis of thermometric parameters of these molecules was carried out.

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Determining the mechanism of interaction between molecules of porphyrin and fullerene and gold nanoparticles, based on luminescence spectroscopy data

Cited by 3 publications

References 18 publications

Porphyrin–Gold Nanomaterial for Efficient Drug Delivery to Cancerous Cells

Porphyrin–Gold Nanomaterial for Efficient Drug Delivery to Cancerous Cells

Fluorescent Ratiometric Thermometers Based on Dyads of Tetraphenylporphyrin and Zinc Metalated Tetraphenylporphyrin

Fluorescent ratiometric thermometers based on dyads of tetraphenyl porphyrin and zinc-metallated tetraphenyl porphyrin

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