Determining the potential targets of silybin by molecular docking and its antibacterial functions on efflux pumps and porins in uropathogenic E. coli

Fekri Kohan, Shirin; Nouhi Kararoudi, Alireza; Bazgosha, Maryam; Adelifar, Somayeh; Hafezolghorani Esfahani, Arman; Ghaderi Barmi, Fatemeh; Kouchakinejad, Reyhaneh; Barzegari, Ebrahim; Shahriarinour, Mahdi; Ranji, Najmeh

doi:10.1007/s10123-024-00488-9

Int Microbiol

2024

DOI: 10.1007/s10123-024-00488-9

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Determining the potential targets of silybin by molecular docking and its antibacterial functions on efflux pumps and porins in uropathogenic E. coli

Shirin Fekri Kohan,

Alireza Nouhi Kararoudi,

Maryam Bazgosha

et al.

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Cited by 2 publications

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Fabrication of chitosan-encapsulated microcapsules containing wood wax oil for antibacterial self-healing wood coatings

Chang,

Wu,

Liu

2024

Industrial Crops and Products

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Fabrication of chitosan-encapsulated microcapsules containing wood wax oil for antibacterial self-healing wood coatings

Chang,

Wu,

Liu

2024

Industrial Crops and Products

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A Comprehensive Review on the Antibacterial, Antifungal, Antiviral, and Antiparasitic Potential of Silybin

Pereira-Filho,

Mendes,

Campos

et al. 2024

Antibiotics

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Silybin, a flavonolignan extracted from the seeds of the plant species Silybum marianum (L.) Gaertn., has a variety of pharmacological activities, including antimicrobial activity against several microorganisms of clinical interest. This review analyzes the existing studies on silybin’s antimicrobial activity and possible mechanisms of action. Silybin has been shown to inhibit the growth of Gram-positive and Gram-negative bacteria, as well as some fungi, viruses, and protozoa. In general, possible mechanisms of antimicrobial action include the inhibition of efflux pumps, prevention of biofilm formation, reduction of the expression of virulence factors, induction of apoptosis-like effects, and plasma membrane damage, as well as the inhibition of nucleic acid and protein synthesis. Silybin has been shown to have synergistic effects when combined with conventional antibiotics against both drug-sensitive and drug-resistant microorganisms. However, the low bioavailability observed for this flavonolignan has been a challenge to its clinical use. In this context, nanotechnology has been used to increase silybin’s bioavailability while enhancing its antimicrobial activity. Furthermore, certain structural modifications have been able to enhance its antimicrobial activity in comparison to that of the natural molecule. Overall, this review provides insights into the scientific understanding of the mechanism of action of silybin and its desired properties for the effective treatment of infections.

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Determining the potential targets of silybin by molecular docking and its antibacterial functions on efflux pumps and porins in uropathogenic E. coli

Cited by 2 publications

References 40 publications

Fabrication of chitosan-encapsulated microcapsules containing wood wax oil for antibacterial self-healing wood coatings

Fabrication of chitosan-encapsulated microcapsules containing wood wax oil for antibacterial self-healing wood coatings

A Comprehensive Review on the Antibacterial, Antifungal, Antiviral, and Antiparasitic Potential of Silybin

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