Determining the Role of Helicobacter pylori in Chronic Sinus Infections Using the Polymerase Chain Reaction

Nikakhlagh, Soheila; Samarbafzadeh, Alireza; Jahani, Mojtaba; Poostchi, Hamed; Kayedani, Gholam Abbas; Naghashpoor, Maryam; Saki, Nader

doi:10.5812/jjm.20783

Cited by 13 publications

(11 citation statements)

References 13 publications

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“…Some but not all studies have shown the association between H. pylori and nasal polyps, but none has established causation yet. Ozdek et al [13] and Nikakhlagh et al [15] found H. pylori DNA in patients with chronic rhinosinusitis using PCR assay. Studies by Vceva et al [23] and Noorbakhsh et al [32] used both PCR and serology and concluded a possible role of H. pylori in emergence of nasal polyps.…”

Section: Resultsmentioning

confidence: 99%

“…It has also been identified in human dental plaques, saliva, in oral lesions and ulcers, and in adenotonsillar tissue [10,11]. Later studies have detected H. pylori in nasal mucosa of chronic rhinosinusitis [12][13][14][15] and nasal polyps [16][17][18][19][20][21][22][23][24] with variable results, which can be attributed to different sample size and detecting methods.…”

Section: Introductionmentioning

confidence: 99%

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Detection of Helicobacter pylori in Nasal Polyps

Bansal

Sharma

Agarwal

et al. 2016

Head and Neck Pathol

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To detect the presence of Helicobacter pylori in nasal polyps. A case-control study was conducted enrolling 35 patients with nasal polyps (cases) and patients undergoing septoplasty (controls). Fresh tissue samples were used for urea broth test and imprint cytology, while formalin fixed tissue sections were used for morphology, special stains and immunohistochemistry for H. pylori. Fresh stool samples from both groups were tested to correlate the gastrointestinal status. H. pylori was detected in 40.0 % (14/35) of cases and 8.5 % of controls (3/35) (p = 0.004) by immunohistochemistry. Amongst cases, eight were positive with urea broth test, six with imprint cytology (Giemsa stain), three with H & E, and nine with modified McMullen's stain. Hyperplasia of the lining epithelium and lymphoid aggregates were significantly noticed in nasal polyps positive for H. pylori. Stool antigen test was positive in subjects who were positive for H. pylori in the nasal mucosa. There appears to be an association between H. pylori and nasal polyps. Immunohistochemistry is more sensitive and specific method to detect H. pylori.H. pylori induced inflammatory tissue reaction pattern indicates a possible causal association. Further studies are needed to prove the causal relationship between H. pylori and nasal polyps.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detection of Helicobacter pylori in Nasal Polyps

Bansal

Sharma

Agarwal

et al. 2016

Head and Neck Pathol

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“…Jelavic et al [44] reported that CRS patients with HP positive samples have statistically significant greater improvement of postoperative endoscopic scores. Nikakhlagh et al [36] reported a significant correlation between CRS and presence of HP in Sino nasal mucosa and documented that this relationship may reflect the role of HP as one of the pathogenic factors in the development of CRS.…”

Section: Discussionmentioning

confidence: 99%

“…Also, Koc et al [34] and Cvorovic et al [35] using urease test could detect HP in nasal polyp specimens obtained from CRS patients but not in any patient with concha bullosa and assured these results by histochemical analysis. Thereafter, Nikakhlagh et al [36] isolated Hp DNA using PCR in 18% of specimens of patients with CRS, but in 4% of patients with concha bullosa without inflamed sinuses. All patients, irrespective of the results of diagnostic tests, received empirical Hp-eradication therapy in the form of 10-day sequential therapy (ST) without any additive specific therapy for nasal sinus disease.…”

Section: Discussionmentioning

confidence: 99%

Empirical 10-day sequential H. pylori eradication therapy could allow sparing of surgical intervention in chronic rhinosinusitis patients

Fatahalla

Wahba

Hasaneen

2019

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

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Objective:To determine the association between H. pylori (Hp) infection and subjective and objective chronic rhinosinusitis (CRS) parameters and to evaluate the effect of empirical Hp-eradication therapy using the 10-day sequential therapy (ST) on these parameters. Patients and Methods:The study included 85 patients with manifestations of CRS, completed questionnaire to determine total subjective score (TSS) and underwent flexible nasal endoscopy, CT imaging, Urea Breath Test (UBT) and stool Hpantigen test. Patients were divided as Hp+ or Hp-. All patients received 10-day ST and responders were re-evaluated 3-m later, but non-responders were given another 10-day ST course and re-evaluated. Non-responders to ST courses and responders who developed recurrent symptoms underwent FESS. Results: 17 patients (20%) were Hp+; 11 in study and 6 in control groups. 12 Hp+ patients (70.5%) and 23 Hp-patients (33.8%) responded to ST, 5 Hp+ patients were assigned to 2nd ST course and 48 patients underwent FESS. Three of Hp+ patients responded to the 2nd ST course, while two underwent FESS. Seven of the responders to 1 st ST course had recurred manifestations and underwent FESS, while 27 patients completed their follow-up uneventfully. Conclusion: Hp infection may underlie chronicity of CRS and is correlated with severity scores. 10-day ST for Hp eradication is being effective within short-time trial. Empirical ST provided improvement of CRS scoring and spared or postponed surgery in about 31.8% of patients, irrespective of being Hp+ or Hp-, so it is advocated as a first-line trial for patients presenting with symptoms suggestive of CRS.

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“…Helicobacter pylori DNA has been detected in a number of extragastric locations, such as the oral cavity, tonsils and adenoids (1,2) , and even the middle ear and paranasal sinuses (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) . However, the significance of the microorganism's presence at these aero-digestive and respiratory sites is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori in both the sinuses and the stomach

Dinis¹,

Matos²,

Sardinha³

et al. 2018

RHINOL

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Background: The role played by Helicobacter pylori in the sinuses, and its association with the same organism's gastric infection, are still unclear. Methods: In order to compare H.pylori colonization patterns in the nose and stomach we conducted a cohort analysis of 14 patients, eligible for sinus surgery due to chronic medically refractory rhinosinusitis, who were tested for simultaneous presence of H. pylori, by histology, culture and polymerase chain reaction, in pathologic sinus tissue collected during surgery and in gastric mucosa obtained through gastroduodenal endoscopy. Results: H. pylori DNA was found in the sinus mucosa of 15.4% of patients with chronic rhinosinusitis, and all of them showed concurrent H. pylori stomach infection. Sinus colonization was not found without simultaneous gastric colonization, although most patients with gastric infection did not have the bacterial DNA in their sinuses. H. pylori's presence in the nose was not associated with local inflammatory status, and no cultures could be obtained from any of the sinus tissue samples, including those positive for H. pylori DNA. Conclusions: Only H. pylori DNA, and not the culturable active form of the microorganism, could be found in the sinus mucosa of some patients with H. pylori gastric infection. We could not find evidence, however, that the bacterium's presence in the nose contributes to local mucosal inflammation.

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Determining the Role of Helicobacter pylori in Chronic Sinus Infections Using the Polymerase Chain Reaction

Cited by 13 publications

References 13 publications

Detection of Helicobacter pylori in Nasal Polyps

Detection of Helicobacter pylori in Nasal Polyps

Empirical 10-day sequential H. pylori eradication therapy could allow sparing of surgical intervention in chronic rhinosinusitis patients

Helicobacter pylori in both the sinuses and the stomach

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