Determining ‘true’ glomerular filtration rate in healthy adults using infusion of inulin and comparing it with values obtained using other clearance techniques or prediction equations

Abstract

Plasma and renal clearance of iohexol and inulin were similar in healthy adults. Underestimation of GFR was noted when plasma clearance of iohexol and inulin was based on four but not five or more blood samples. Some prediction equations underestimate true GFR to such an extent that caution must be taken when using them to evaluate normal or high GFR values.

Assessment of Glomerular Filtration Rate Measurement with Plasma Sampling: A Technical Review

“…Inulin has the properties of an ideal tracer but is rarely used clinically (9). It is the gold standard for measuring GFR but is technically difficult to use, is expensive and timeconsuming, requires multiple urine samples, and is problematic in patients with urologic disease and in children.…”

GFR Normalized to Total Body Water Allows Comparisons across Genders and Body Sizes

“…This method has been validated against gold standard methods for measuring GFR. [23][24][25][26][27][28][29] The subjects were instructed to avoid large meals with meat and nonsteroid anti-inflammatory drugs for 2 days before the investigation. The measurements were performed after fasting and abstinence from nicotine.…”

Validation of a new plasma cystatin C-based formula and the Modification of Diet in Renal Disease creatinine-based formula for determination of glomerular filtration rate

“…In normal renal function GFR estimation using formulae based on creatinine gives falsely low values [5]. In comparison with the optimal renal inulin clearance for determination of GFR, four formulae based on plasma creatinine underestimated GFR by 10Á25% [42]. In situations where accurate values of GFR are important, e.g.…”