Determining Visfatin / NAMPT Serum Levels by ELISA Technique, in Pregant Women with Preeclampsia

Hognogi, Larisa Diana Mocan; Hognogi, Mocan Radu Florin; Măluţan, Andrei Mihai; Fărcăş, Anca Daniela; Simiti, Luminita Vida

doi:10.37358/rc.17.9.5833

Cited by 7 publications

(4 citation statements)

References 7 publications

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“…Hypertension does not seem to alter visfatin plasma levels. Our study, conducted on two different types of hypertensive patients, also confirms these findings [ 18 ].…”

Section: Adipokines As Biomarkers In Atherosclerotic Heart Diseasesupporting

confidence: 88%

Usefulness of the Adipokines as Biomarkers of Ischemic Cardiac Dysfunction

2018

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Cardiovascular disease is the leading cause of death among both women and men, but there is still a great percentage of misdiagnosis and lack of clearly defined criteria. Advances in biomolecular science have proven the crucial role of inflammation and, more importantly, the role of adipokines in mediating all stages of coronary artery disease. It has also been suggested that regional fat deposits, more precisely from thoracic region, have a major influence on the development of coronary artery disease by creating a local proatherogenic environment. The immune system closely interacts with metabolic risk factors to initiate, promote, and further aggravate the atherosclerotic lesions on the arterial wall all with the “help” of adipokines. So nowadays, research extensively focuses on uncovering biomarkers that would provide an increased chance of detecting subclinical cardiac distress and also add a consistent value to current guideline-imposed risk criteria.

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“…Hypertension does not seem to alter visfatin plasma levels. Our study, conducted on two different types of hypertensive patients, also confirms these findings [ 18 ].…”

Section: Adipokines As Biomarkers In Atherosclerotic Heart Diseasesupporting

confidence: 88%

Usefulness of the Adipokines as Biomarkers of Ischemic Cardiac Dysfunction

2018

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“…Leptin is a proatherogenic adipokine, which is excessively secreted in obese patients, together with other adipokines with similar effects, such as resisitin [20] or visfatin [21]. Overweight and obese patients with heart failure are hyperleptinemic.…”

Section: Resultsmentioning

confidence: 99%

Can the Presence of Atrial Fibrillation Influence the Levels of Heart Failure - Specific Biomarkers in Overweight and Obese Patients With Heart Failure?

Dădârlat¹,

Pop²,

Fărcăş³

et al. 2019

Rev. Chim.

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Heart failure continues to be a major worldwide medical issue, associated with high morbidity and mortality. The need for ideal biomarkers to aid the diagnosis and prognosis in certain situations, such as obesity or atrial fibrillation is still ongoing. Obese patients are commonly hyperleptinemic. The aim of the study is to assess the role of several biomarkers in overweight and obese patients diagnosed with heart failure, depending on the presence or absence of atrial fibrillation and also their relationship with leptin. The study included 88 overweight and obese patients, with a body mass index (BMI) ≥25 kg/m2, admitted for worsening heart failure. Of these, 52.2% had atrial fibrillation. Dosage of NT-proBNP was performed using the chemiluminescence method. MR-proANP, galectin-3 and leptin were dosed using the ELISA method. A value of P [0.05 was defined as statistically significant. The values of natriuretic peptides NT-proBNP and MR-proANP were significantly increased. Only NT-proBNP was significantly influenced by renal function. No statistically significant correlation was found between heart failure-specific biomarkers and leptin secretion. There were no significant differences in the biomarkers levels between the 2 groups of patients. No statistically significant correlation was found between heart failure-specific biomarkers and leptin secretion. Obese patients with heart failure had significantly increased values of all the studied parameters, but the presence of atrial fibrillation did not influence their levels. High leptin levels were not directly correlated with the levels of heart failure-specific biomarkers.

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“…Preeclampsia, a systemic vascular disease, may affect various organs, leading to severe complications of the fetus and of the pregnant mother. Even if precise causes that determine preeclampsia are not yet established, several studies have shown, that placental dysfunctions play an important role in the emergence of this disease, being correlated to the subsequent maternal endothelial disfunctions [1,2]. The anatomical presentation of placenta in case of pregnant women suffering from severe preeclampsia has frequently shown the presence of infarcts, fibrinoid necrosis of the blood vessels walls, thrombosis and signs of chronic inflammation [1,3].…”

Section: Gestational Hypertensionmentioning

confidence: 99%

The Role of Several Angiogenesis Peptides Markers in the Management of Hypertensive Pregnant Women

Mihălceanu¹,

Dimitriu²,

Lazar³

et al. 2018

Rev. Chim.

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The objectives of the research herein are to detect if the modifications of sFlt-1 and PlGF can be correlated with the clinical and biochemical status of the hypertensive pregnant woman and if the sFlt-1/PlGF ratio is a good predictor for preeclampsia in case of the investigated patients. In the study herein, 100 pregnant women were evaluated; they were distributed in the following groups: The group of pregnant women diagnosed with HTN at the time of hospital admission � including 50 pregnant women, of which 16 pregnant women presented medium and severe forms of preeclampsia and 34 pregnant women with pregnancy-induced hypertension and 50 pregnant women with normal pregnancy evolution as control group. We have performed hematological and biochemical tests, using serum samples from all analyzed patients and measured the serum concentrations of sFlt-1 and PlGF angiogenic factors. We found a significant correlation between the value of the arterial blood pressure, the proteinuria, the serum creatinine and the AST, on one hand, and the sFlt-1/PlGF ratio, on the other hand. The ROC curve has emphasized the fact that the proteinuria (AUC = 0.849), the AST (AUC = 0.664), the value of the arterial blood pressure SBP/DBP (AUC = 0.683/0.631), the serum creatinine (AUC = 0.674) and the sFlt-1/PlGF ratio, at a cut off value = 200, are effective preeclampsia predictors. Similarly, statistically significant increase (p = 0.001) of the sFlt-1 serum concentration in case of the pregnant women from the PE group (14365�6464 pg/mL) and from the PIH group (9892�8443 pg/mL), compared to the control group (3278�1444 pg/mL) and, respectively, a significant decrease (p = 0.003) of the PlGF pro-angiogenic marker for the group of pregnant women suffering from preeclampsia (119.30�56.63 pg/mL) and from PIH (129.12�21.41 pg/mL), compared to the control group (327.57�59.62 pg/mL). The results obtained within this research show that sFlt-1/PlGF ratio represents an effective preeclampsia predictor, confirming the fact that the study of the angiogenic factors may help to analyze the stratification of the risk degree in HTN pregnant women.

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Determining Visfatin / NAMPT Serum Levels by ELISA Technique, in Pregant Women with Preeclampsia

Cited by 7 publications

References 7 publications

Usefulness of the Adipokines as Biomarkers of Ischemic Cardiac Dysfunction

Usefulness of the Adipokines as Biomarkers of Ischemic Cardiac Dysfunction

Can the Presence of Atrial Fibrillation Influence the Levels of Heart Failure - Specific Biomarkers in Overweight and Obese Patients With Heart Failure?

The Role of Several Angiogenesis Peptides Markers in the Management of Hypertensive Pregnant Women

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