In this work, a deflagration-to-detonation transition in drop mixtures of hydrocarbon fuel with air was experimentally detected for the first time. It is shown that a Shchelkin spiral and a new element, a coil of the tube, significantly decrease the detonation initiation energy and the predetonation distance.There are several ways to decrease the predetonation distance in gaseous explosive mixtures. Laffitte [1,2] experimentally demonstrated that a decrease in the tube diameter and an increase in the initial pressure of an explosive mixture decrease the predetonation distance. Shchelkin [3] revealed that the aerodynamic conditions in the channel play a leading role in the deflagration-to-detonation transition. He showed that, if an obstacle in the form of a wire spiral (a Shchelkin spiral) is placed in the channel, the predetonation distance decreases considerably. Shchelkin and Sokolik [4] detected a decrease in the predetonation distance after preliminary heat treatment of fuel. Brophy et al. [5] showed that the predetonation distance in the case of ignition of a mixture by a nanosecond corona discharge in combination with a Shchelkin spiral is smaller than that in the case of ignition of a mixture by an arc discharge. We previously [6] proved experimentally that the predetonation distance can be significantly decreased by accelerating a weak shock wave by a traveling forced ignition pulse, i.e., using an idea that was first proposed by Zel'dovich and Kompaneets [7].Unlike the deflagration-to-detonation transition in gaseous mixtures, the deflagration-to-detonation transition in drop mixtures of liquid fuel with air (oxygen) is virtually unstudied. In available experimental studies [8-10], heterogeneous ("drop") detonation was initiated by strong sources: a shock wave [8], gas detonation [9], or an explosive charge [10]. Earlier [11,12], we initiated detonation of sprays of liquid fuel in air by one or two electric discharges. In drop mixtures of liquid fuel with gaseous oxygen, a deflagration-to-detonation transition was observed by Pierce and Nicholls [13], who reported that the predetonation distance was 20-100 tube calibers long. Data on experimental observations of deflagration-to-detonation transitions in drop mixtures of hydrocarbon fuels with air are unavailable in the literature. In the context of increasing interest in the practical use of detonation combustion in aircraft engines and power engineering [14], it is topical to study a deflagration-to-detonation transitions in drop mixtures of hydrocarbon fuel with air.The purpose of this work was to use combined means for attaining a deflagration-to-detonation transition and decreasing the predetonation distance in drop hydrocarbon-air mixtures.Previously [11,12], we studied detonation initiation in the flow of a drop n -hexane-air mixture in a ( 1.3 ± 0.1)-fold excess of fuel under normal conditions in a 1.5-m-long tube 51 mm in diameter, which was equipped with a full-flow air-assist atomizer at one end and a detonation arrester at the other. Ignition...