Detonation nanodiamonds simultaneously purified and modified by gas treatment

Petrov, I.; Shenderova, Olga; Grishko, Victor I.; Grichko, Varvara P.; Tyler, Talmage; Cunningham, G.; McGuire, G. E.

doi:10.1016/j.diamond.2007.05.013

Cited by 94 publications

(44 citation statements)

References 11 publications

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“…Interestingly, our studies indicate negatively charged NDs were still able to adsorb the toxin, despite charge repulsion, while negatively charged HSCAS clay minerals, whose binding is based on electrostatics, shows little to no adsorption of OTA. 45,49 Though adsorption is lower in negatively charged NDs, the presence of oxygen containing groups, specifically carboxyls on I6-COOH, OZ-ND, OZ-Bl and RUDDM1, 38,50 exhibit the reason for binding. Previous studies using charged dye molecules showed no adsorption on NDs of like charges, 34,38 insinuating that electrostatic interactions dominate adsorption but are not the sole mechanism.…”

Section: B Ochratoxin Amentioning

confidence: 99%

Immobilization of mycotoxins on modified nanodiamond substrates

et al. 2011

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The effectiveness of modified nanodiamonds (NDs) for the adsorption of mycotoxins, aflatoxin B1 (AfB1) and ochratoxin A (OTA), are investigated in this paper. Binding and release mechanisms of the mycotoxins were addressed using an assortment of NDs modified by different surface treatments, including carboxylation, hydrogenation and hydroxylation, followed by isolating NDs of different sizes. Results indicate that AfB1 adsorption on NDs is directly related to aggregate size, whereas OTA adsorption is primarily centered upon electrostatic interactions that depend on the types of surface functional groups on the ND. Findings show that modified NDs with small aggregation sizes (~40 nm) have greater adsorption capacities for AfB1 than yeast cells walls and untreated NDs from various vendors, but comparable to activated charcoal. In OTA studies, positively charged NDs outperformed clay minerals, which are well-known and efficient sorbents for mycotoxins. Furthermore, ND adsorption capacities can be preserved in a wide range of pH.

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Section: B Ochratoxin Amentioning

confidence: 99%

Immobilization of mycotoxins on modified nanodiamond substrates

et al. 2011

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“…Oxidation of ND using singlet oxygen in liquid media or ozone could modify ND with carboxylic acid groups on the surface and improve dispersity in the aqueous solution. 13 In addition, modified ND can be used in various ND-drug conjugations, such as doxorubicin, menthol, and plant metabolites. [14][15][16] Topical drug delivery systems are composed of various ingredients such as an ointment base, emulsifying agent, thickening agent, preservative, buffering agent, vehicle, antioxidant, and permeation enhancer.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive evaluation of carboxylated nanodiamond as a topical drug delivery system

Lim¹,

Kim²,

Kang³

et al. 2016

IJN

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The best strategy in the development of topical drug delivery systems may be to facilitate the permeation of drugs without any harmful effects, while staying on the skin surface and maintaining stability of the system. Nanodiamonds (NDs) play a key role with their excellent physicochemical properties, including high biocompatibility, physical adsorption, reactive oxygen species (ROS) scavenging capability, and photostabilizing activity. Z -average sizes of carboxylated ND (ND–COOH) agglutinate decreased significantly as the pH increased. Fluorescein-conjugated ND was observed only on the stratum corneum, and no sample diffused into the dermal layer even after 48 hours. Moreover, ND–COOH and ND–COOH/eugenol complex did not show significant toxic effects on murine macrophage cells. ND improved in vitro skin permeation >50% acting as a “drug reservoir” to maintain a high drug concentration in the donor chamber, which was supported by quartz crystal microbalance results. Moreover, ND–COOH could adsorb a drug amount equivalent to 80% of its own weight. A photostability study showed that ND–COOH increased the photostability ~47% with regard to rate constant of the eugenol itself. A significant decrease in ROS was observed in the ND–COOH and ND–COOH/eugenol complex compared with the negative control during intracellular ROS assay. Moreover, ROS and cupric reducing antioxidant capacity evaluation showed that ND–COOH had synergistic effects of antioxidation with eugenol. Therefore, ND–COOH could be used as an excellent topical drug delivery system with improved permeability, higher stability, and minimized safety issue.

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“…Lithium Aluminum hydride (Hens et al 2008;Zheng et al 2009; -Ozone (Petrov et al 2007;Krüger et al 2006) -Air (Mochalin and Gogotsi 2009;Osswald et al 2006;Shenderova et al 2006;John et al 2003;Mitev et al 2007) ND ND Oxidation Reduction ND Fig. 2 A nanodiamond with a mixed composition of surface groups can be oxidised and terminated with oxygencontaining functional groups or reduced to produce a homogeneous hydrogen surface termination bead milling and sonication (Krüger et al 2005;Fu et al 2007;Faklaris et al 2008).…”

Section: Oxidation/carboxylation Reductionmentioning

confidence: 99%

Luminescent nanodiamonds for biomedical applications

et al. 2011

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In recent years, nanodiamonds have emerged from primarily an industrial and mechanical applications base, to potentially underpinning sophisticated new technologies in biomedical and quantum science. Nanodiamonds are relatively inexpensive, biocompatible, easy to surface functionalise and optically stable. This combination of physical properties are ideally suited to biological applications, including intracellular labelling and tracking, extracellular drug delivery and adsorptive detection of bioactive molecules. Here we describe some of the methods and challenges for processing nanodiamond materials, detection schemes and some of the leading applications currently under investigation.

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Detonation nanodiamonds simultaneously purified and modified by gas treatment

Cited by 94 publications

References 11 publications

Immobilization of mycotoxins on modified nanodiamond substrates

Immobilization of mycotoxins on modified nanodiamond substrates

Comprehensive evaluation of carboxylated nanodiamond as a topical drug delivery system

Luminescent nanodiamonds for biomedical applications

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