Detoxification and functionalization of gold nanorods with organic polymers and their applications in cancer photothermal therapy

Jin, Na; Zhang, Qing; Yang, Manyi; Yang, Mingying

doi:10.1002/jemt.23213

Cited by 11 publications

(14 citation statements)

References 64 publications

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“…When AuNR was used as a photothermal core, on-demand controllable drug release from the shell reservoir could be triggered by light excitation [ 23 ]. However, limited choices have been given for shell materials due to their low drug loading capability, toxic synthetic approaches, time-consuming synthesis, and high tendency in causing aggregation [ 24 , 25 ]. Therefore, in order to achieve the full potential of chemo-photothermal therapy, it is critical to choose biocompatible, biodegradable, and reliable shell materials.…”

Section: Introductionmentioning

confidence: 99%

Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy

Huang

Jiang

et al. 2021

J Nanobiotechnol

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Chemo-photothermal therapy based on nanoparticles has emerged as a promising strategy for cancer treatment. However, its therapeutic efficacy and application potential are largely subjected to the uncontrollability and biotoxicity of functional nanoplatforms. Herein, a novel biocompatible and biodegradable metal organic framework (MOF), which was constructed by growing crystalline zeolitic imidazolate framework-8 on gold nanoroad (Au@ZIF-8), was designed and fabricated for efficient drug loading and controlled release. Owing to the large surface area and guest-matching pore size of ZIF-8, doxorubicin (DOX) was successfully loaded into the Au@ZIF-8 with a high drug loading efficiency of ~ 37%. Under NIR light or weakly acidic environment, the ZIF-8 layer was quickly degraded, which resulted in an on-demand drug release in tumour site. More importantly, under the irradiation of near infrared (NIR) laser, highly efficient cancer treatment was achieved in both in vitro cell experiment and in vivo tumour-bearing nude mice experiment due to the synergistic effect of photothermal (PTT) therapy and chemotherapy. In addition, the in vivo study revealed the good biocompatibility of Au@ZIF-8. This work robustly suggested that Au@ZIF-8 could be further explored as a drug delivery system for chemo-photothermal synergistic therapy.

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Section: Introductionmentioning

confidence: 99%

Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy

Huang

Jiang

et al. 2021

J Nanobiotechnol

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“…Jin et al reported that, though Au NPs attained great importance in cancer phototherapy, they have a limitation of surface toxicity. To reduce this, Au NPs need to be coated with organic polymers . There are advantages and disadvantages of organic polymer coating on gold nanorods; thus, further modification is essential to coating gold nanorods with polymer .…”

Section: Theragnostic Application Of Biopolymer For Anticancer Therapymentioning

confidence: 99%

Advancement in Biopolymer Assisted Cancer Theranostics

Bhattacharya,

Preetam,

Ghosh

et al. 2023

ACS Appl. Bio Mater.

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Applications of nanotechnology have increased the importance of research and nanocarriers, which have revolutionized the method of drug delivery to treat several diseases, including cancer, in the past few years. Cancer, one of the world’s fatal diseases, has drawn scientists’ attention for its multidrug resistance to various chemotherapeutic drugs. To minimize the side effects of chemotherapeutic agents on healthy cells and to develop technological advancement in drug delivery systems, scientists have developed an alternative approach to delivering chemotherapeutic drugs at the targeted site by integrating it inside the nanocarriers like synthetic polymers, nanotubes, micelles, dendrimers, magnetic nanoparticles, quantum dots (QDs), lipid nanoparticles, nano-biopolymeric substances, etc., which has shown promising results in both preclinical and clinical trials of cancer management. Besides that, nanocarriers, especially biopolymeric nanoparticles, have received much attention from researchers due to their cost-effectiveness, biodegradability, treatment efficacy, and ability to target drug delivery by crossing the blood–brain barrier. This review emphasizes the fabrication processes, the therapeutic and theragnostic applications, and the importance of different biopolymeric nanocarriers in targeting cancer both in vitro and in vivo, which conclude with the challenges and opportunities of future exploration using biopolymeric nanocarriers in onco-therapy with improved availability and reduced toxicity.

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“…Among them, organic polymers are intensively investigated due to their low toxicity and easy access to modification with functional groups, such as targeting molecules on the tumor cell surface, and imaging agents, such as radioactive elements. According to these data, the detoxification and functionalization of gold nanorods with organic polymers might allow their introduction in clinical practice and their application in cancer photothermal therapy [91]. The size of the gold nanoparticles represents the main factor determining toxicity.…”

Section: Toxicity Of Aunpsmentioning

confidence: 99%

Gold Nanoparticles: A New Golden Era in Oncology?

et al. 2020

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In recent years, the spectrum of possible applications of gold in diagnostics and therapeutic approaches in clinical practice has changed significantly, becoming surprisingly broad. Nowadays, gold-based therapeutic agents are used in the therapy of multiple human diseases, ranging from degenerative to infectious diseases and, in particular, to cancer. At the basis of these performances of gold, there is the development of new gold-based nanoparticles, characterized by a promising risk/benefit ratio that favors their introduction in clinical trials. Gold nanoparticles appear as attractive elements in nanomedicine, a branch of modern clinical medicine, which combines high selectivity in targeting tumor cells and low toxicity. Thanks to these peculiar characteristics, gold nanoparticles appear as the starting point for the development of new gold-based therapeutic strategies in oncology. Here, the new gold-based therapeutic agents developed in recent years are described, with particular emphasis on the possible applications in clinical practice as anticancer agents, with the aim that their application will give rise to a new golden age in oncology and a breakthrough in the fight against cancer.

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Detoxification and functionalization of gold nanorods with organic polymers and their applications in cancer photothermal therapy

Cited by 11 publications

References 64 publications

Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy

Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy

Advancement in Biopolymer Assisted Cancer Theranostics

Gold Nanoparticles: A New Golden Era in Oncology?

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