Detoxification Impacts of Ascorbic Acid and Clay on Laying Japanese Quail Fed Diets Polluted by Various Levels of Cadmium

Abou-Kassem, Diaa E.; El‐Hack, Mohamed E. Abd; Taha, Ayman E.; Ajarem, Jamaan S.; Maodaa, Saleh N.; Allam, Ahmed A.

doi:10.3390/ani10030372

Cited by 13 publications

(14 citation statements)

References 37 publications

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“…In a lifelong experiment [9] evaluating the survival of animals exposed to cadmium, more individuals survived (one-year survival was also 100% as confirmed by the experiments) compared to other heavy metals. This may be because cadmium in low doses may function as an essential element [10][11][12]. Hijová et al [13] also did not report any death of exposed animals during a chronic experiment in rats lasting 90 days, administering CdCl 2 in drinking water per os with a predicted daily dose of cadmium of 2.5 mg•kg −1 , similar to this study.…”

Section: Toxicological Parameterssupporting

confidence: 83%

Simulation of Chronic Intoxication in Rats Exposed to Cadmium and Mercury

et al. 2020

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Cadmium and mercury are widespread and non-biodegradable pollutants of great concern to human and animal health. In this study, the influence of exposure to low doses of cadmium and mercury on Wistar rats was investigated. The experiments aimed to identify suitable markers of chronic intoxication with heavy metals in rats. The subjects were 48 naive young rats (24 females and 24 males), four weeks old, grouped randomly into three distinct groups—control group, group exposed to cadmium and group exposed to mercury. The control group received sham treatment—clean untreated water. Cd exposed group received water containing cadmium chloride dihydrate and Hg exposed group received water with mercury dichloride. Both cadmium and mercury were administered to experimental rats in drinking water in concentrations exceeding the maximum acceptable concentration of these metals 500 times, i.e., 0.5 mg Hg and 2.5 mg Cd per liter of water. The results were evaluated quarterly during the experiment (52 weeks). Selected physiological parameters (life span, body weight changes and intake of food and water), reproductive parameters (number of births (litters), number of born pups and number of raised pups) and toxicological parameters (average daily dose, total dose received and the amount of toxic metal received) were studied. The results of the experiments indicate differences between both individual groups and between males and females, which confirmed that these parameters are essential in such experiments of chronic exposure to subtoxic doses of heavy metals.

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Section: Toxicological Parameterssupporting

confidence: 83%

Simulation of Chronic Intoxication in Rats Exposed to Cadmium and Mercury

et al. 2020

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“…Furthermore, feedstuffs, drinking water, inspired cigarette smoke or polluted air, and absorption of polluted soil and dust created by people and animals that have earlier collected Cd in their biological cells are also causes of Cd exposure [ 7 ]. Indeed, Cd is a non-biodegradable, poisonous element with a prolonged biological half-life and is harmful to plants, humans, and animals [ 8 ]. Several attempts by national organizations and government agencies to limit Cd usage have been applied.…”

Section: Introductionmentioning

confidence: 99%

“…Despite low concentrations of Cd subjection in the renal tissue, it accumulates in the tubular epithelium in the form of a Cd-metallothionein complex, leading to proximal tubular dysfunction [ 8 ]. Several experiments have shown that Cd-stimulated renal toxicity is mediated by the liberation of Cd-metallothionein compounds from impaired Kupffer cells, which are refined by the glomerulus, endocytosed through the proximal tubular cells, and destroyed by lysosomes after Cd accumulation [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Renoprotective and Oxidative Stress-Modulating Effects of Taxifolin against Cadmium-Induced Nephrotoxicity in Mice

Algefare

2022

Life

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Cadmium (Cd) is an inessential trace metal that accumulates in the kidney and may lead to renal toxicity by mediating oxidative stress (OS), inflammatory reactions, and apoptosis. The main objective of this experiment was to inspect the protecting potential of taxifolin (TA) on Cd-induced renal toxicity. Adult male mice were allocated into equal five groups as follows: control, TA-treated (50 mg/kg, oral), CdCl2-treated (4 mg/kg body weight (BW), p.o.), pretreated with TA (25 mg/kg) 1 h before CdCl2 injection (4 mg/kg BW, p.o.), and pretreated with TA (50 mg/kg) 1 h before CdCl2 injection (4 mg/kg BW, p.o.) for 14 days. Cd-intoxicated mice revealed higher serum urea and creatinine levels and notable histopathological alterations in the renal tissues. Malondialdehyde (MDA), nitric oxide (NO), nuclear factor-kappa B (NF-κB) p65, tumor necrosis factor-α (TNF-α), and IL-1β were increased. In contrast, glutathione levels, catalase and superoxide dismutase activities, and IL-10 levels were decreased under Cd-administered effects. Conversely, the TA pre-treatment highly protected tissues from Cd-toxicity, improved renal function, decreased MDA and NO levels, attenuated inflammation, and improved redox status in the renal tissues of Cd-intoxicated mice. The TA pre-treatment of Cd-intoxicated mice showed down-regulation of both Bax and caspase-3 protein and up-regulation of Bcl-2 protein expression in the kidney. Furthermore, TA pre-treatment induced higher upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) expression in kidney cells of Cd-intoxicated mice. Therefore, TA can protect renal tissues against Cd-induced nephrotoxicity via improving redox status, modulating inflammation, diminishing cell apoptosis, and activating the Nrf2/HO-1 signaling pathway.

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“…There are only a few studies on egg quality parameters of cadmium. Abou-Kassem et al [4] reported that ascorbic acid or natural clay decreases the negative effects of Cd and improves some egg quality traits of laying Japanese quails. Korénekova et al [23] found that Cd (0.12 mg/day per quail) had adverse effects on the quality parameters of eggs.…”

Section: Resultsmentioning

confidence: 99%

“…Cadmium toxicity causes oxidative stress, an increase in metallothionein synthesis, as well as impairment in Zn, Ca, and Fe metabolism, enzyme functions, and plasma membrane integrity. Vitamins, minerals, and herbs have been studied to reduce the negative effects of cadmium, but few studies have been conducted on poultry [1,3,4,5]. Based on these studies, it has been reported that some dietary supplements may be effective against cadmium toxicity.…”

Section: Introductionmentioning

confidence: 99%

The effects of dietary calcium tetraborate on the ovalbumin levels and some egg quality traits in laying quails exposed to cadmium

Mutlu¹,

Baykalir²,

Iflazoglu³

et al. 2021

GSC Biol. and Pharm. Sci.

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Cadmium (Cd) is a toxic heavy metal and one of the most important environmental pollutant that is derived from agricultural and industrial sources. Boron (B) is a metalloid that has beneficial physiological effects on the metabolism of animals and humans. This research is aimed at investigating the effect of calcium tetraborate (CaB4O7) on the ovalbumin levels of quail’s egg and some egg quality traits in laying quails exposed to Cd. For this purpose, one hundred twenty Japanese quail 6-week-old were randomly divided into 4 groups (5 replicates each). During the 8 weeks, quails were fed a basal diet (control) and basal diet supplemented with Cd (100 mg of CdCl2), CaB4O7 (300 mg of CaB4O7), and Cd + CaB4O7 (100 mg of CdCl2 and 300 mg of CaB4O7). A total of 160 eggs including 40 eggs from each group were collected for assessment of the quality of the egg and the ovalbumin level of the eggs. Compared with the Cd group, supplementation of Cd + CaB4O7 increased the egg weight (P < 0.01). Results of this study indicated that dietary supplementation with Cd or CaB4O7 was not affected significantly albumen pH, yolk ratio, and yolk color (P > 0.05). Regarding the egg quality, the significant effect of Cd or CaB4O7 (P < 0.01) was found in shape index, yolk weight, albumen weight, and yolk pH. The dietary combination of Cd and CaB4O7 led to the greatest increases in albumen ratio (P < 0.01). The Cd group had the highest ovalbumin level, while CaB4O7 and Cd + CaB4O7 groups had the same ovalbumin level. The findings of this study revealed that provided new insight into the toxicity of the Cd on ovalbumin level and some egg quality traits and CaB4O7 could be used as a potential strategy to ameliorate Cd toxicity.

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Detoxification Impacts of Ascorbic Acid and Clay on Laying Japanese Quail Fed Diets Polluted by Various Levels of Cadmium

Cited by 13 publications

References 37 publications

Simulation of Chronic Intoxication in Rats Exposed to Cadmium and Mercury

Simulation of Chronic Intoxication in Rats Exposed to Cadmium and Mercury

Renoprotective and Oxidative Stress-Modulating Effects of Taxifolin against Cadmium-Induced Nephrotoxicity in Mice

The effects of dietary calcium tetraborate on the ovalbumin levels and some egg quality traits in laying quails exposed to cadmium

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