Detoxification of Fumonisins by Three Novel Transaminases with Diverse Enzymatic Characteristics Coupled with Carboxylesterase

Wang, Yue; Sun, Junhao; Zhang, Mengwei; Pan, Kungang; Liu, Tianhui; Zhang, Tongcun; Luo, Xue‐Gang; Zhao, Junqi; Li, Zhongyuan

doi:10.3390/foods12020416

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…FumI may be suitable for future use as a feed enzyme ( Hartinger et al, 2010 , 2011 ). Yue Wang reported three fumonisin detoxifying aminotransferases, FumTSTA, FumUPTA, and FumPHTA, that share 61–74% sequence identity with FumIS and FumIB and exhibit good pH and thermal stabilities ( Wang Y. et al, 2023 ).…”

Section: Common Mycotoxins and Corresponding Enzymes Used For Detoxif...mentioning

confidence: 99%

Bioenzymatic detoxification of mycotoxins

Liu,

Zhang,

Luan

et al. 2024

Front. Microbiol.

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Mycotoxins are secondary metabolites produced during the growth, storage, and transportation of crops contaminated by fungi and are physiologically toxic to humans and animals. Aflatoxin, zearalenone, deoxynivalenol, ochratoxin, patulin, and fumonisin are the most common mycotoxins and can cause liver and nervous system damage, immune system suppression, and produce carcinogenic effects in humans and animals that have consumed contaminated food. Physical, chemical, and biological methods are generally used to detoxify mycotoxins. Although physical methods, such as heat treatment, irradiation, and adsorption, are fast and simple, they have associated problems including incomplete detoxification, limited applicability, and cause changes in food characteristics (e.g., nutritive value, organoleptic properties, and palatability). Chemical detoxification methods, such as ammonification, ozonation, and peroxidation, pollute the environment and produce food safety risks. In contrast, bioenzymatic methods are advantageous as they achieve selective detoxification and are environmentally friendly and reusable; thus, these methods are the most promising options for the detoxification of mycotoxins. This paper reviews recent research progress on common mycotoxins and the enzymatic principles and mechanisms for their detoxification, analyzes the toxicity of the degradation products and describes the challenges faced by researchers in carrying out enzymatic detoxification. In addition, the application of enzymatic detoxification in food and feed is discussed and future directions for the development of enzymatic detoxification methods are proposed for future in-depth study of enzymatic detoxification methods.

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Section: Common Mycotoxins and Corresponding Enzymes Used For Detoxif...mentioning

confidence: 99%

Bioenzymatic detoxification of mycotoxins

Liu,

Zhang,

Luan

et al. 2024

Front. Microbiol.

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“…The authors of a very recent study performed gene mining to construct three novel fumonisin transaminases (aminotransferases) [ 152 ]. These enzymes called FumTSTA, FumUPTA, and FumPHTA were from Paraburkholderia madseniana (FumTSTA) and Phenylobacterium sp.…”

Section: Biotransformation Of Fumonisin B1mentioning

confidence: 99%

“…The revealed candidate enzymes should be then tested for their real substrate-degrading activity and degradation products. As examples, we can mention the study [ 149 ], where the authors used gene mining to reveal a novel carboxylesterase FumDSB from Sphingomonadales bacterium , and the study [ 152 ] resulted in the revealing of three novel fumonisin aminotransferases FumTSTA, FumUPTA, and FumPHTA from Paraburkholderia madseniana and Phenylobacterium sp. In some cases, additional computational tools can be used.…”

Section: Prospects For Use Of Microbial Destructors Of Fusariotoxins ...mentioning

confidence: 99%

Post-Harvest Prevention of Fusariotoxin Contamination of Agricultural Products by Irreversible Microbial Biotransformation: Current Status and Prospects

Statsyuk

Popletaeva

Щербакова

2023

BioTech

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Biological degradation of mycotoxins is a promising environmentally-friendly alternative to chemical and physical detoxification methods. To date, a lot of microorganisms able to degrade them have been described; however, the number of studies determining degradation mechanisms and irreversibility of transformation, identifying resulting metabolites, and evaluating in vivo efficiency and safety of such biodegradation is significantly lower. At the same time, these data are crucial for the evaluation of the potential of the practical application of such microorganisms as mycotoxin-decontaminating agents or sources of mycotoxin-degrading enzymes. To date, there are no published reviews, which would be focused only on mycotoxin-degrading microorganisms with the proved irreversible transformation of these compounds into less toxic compounds. In this review, the existing information about microorganisms able to efficiently transform the three most common fusariotoxins (zearalenone, deoxinyvalenol, and fumonisin B1) is presented with allowance for the data on the corresponding irreversible transformation pathways, produced metabolites, and/or toxicity reduction. The recent data on the enzymes responsible for the irreversible transformation of these fusariotoxins are also presented, and the promising future trends in the studies in this area are discussed.

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Fluorescent microsphere immunochromatographic sensor for the detection of total fumonisins B1, B2, and B3 in grain samples

Li,

Feng

et al. 2024

Journal of Food Composition and Analysis

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Detoxification of Fumonisins by Three Novel Transaminases with Diverse Enzymatic Characteristics Coupled with Carboxylesterase

Cited by 4 publications

References 39 publications

Bioenzymatic detoxification of mycotoxins

Bioenzymatic detoxification of mycotoxins

Post-Harvest Prevention of Fusariotoxin Contamination of Agricultural Products by Irreversible Microbial Biotransformation: Current Status and Prospects

Fluorescent microsphere immunochromatographic sensor for the detection of total fumonisins B1, B2, and B3 in grain samples

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