Detoxification of patulin from juice simulator and apple juice via cross-linked Se-chitosan/L-cysteine nanoparticles

Paimard, Giti; Mohammadi, Reza; Bahrami, Roya; Khosravi‐Darani, Kianoush; Sarlak, Zahra; Rouhi, Milad

doi:10.1016/j.lwt.2021.111146

Cited by 23 publications

(8 citation statements)

References 47 publications

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“…Both products contain an aldehyde group with high activation and electrophilic properties, which can react with cysteine (nucleophilic agent) to form their adducts ( Figure 7 ). The third is forming hydrogen bonds and covalent bonds between patulin and cysteine (-SH and -NH 2 groups) in high-acid and high-temperature environments [ 27 , 28 , 29 ]. These inferred mechanisms should be further verified based on the analysis of Fourier transform infrared spectra (FTIR), mass spectroscopy (MS), nuclear magnetic resonance (NMR), and thin-layer chromatography (TLC) in the next work.…”

Section: Discussionmentioning

confidence: 99%

Thermal Stability and Degradation Kinetics of Patulin in Highly Acidic Conditions: Impact of Cysteine

Diao

Zhang

et al. 2021

Toxins

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The thermal stability and degradation kinetics of patulin (PAT, 10 μmol/L) in pH 3.5 of phosphoric-citric acid buffer solutions in the absence and presence of cysteine (CYS, 30 μmol/L) were investigated at temperatures ranging from 90 to 150 °C. The zero-, first-, and second-order models and the Weibull model were used to fit the degradation process of patulin. Both the first-order kinetic model and Weibull model better described the degradation of patulin in the presence of cysteine while it was complexed to simulate them in the absence of cysteine with various models at different temperatures based on the correlation coefficients (R2 > 0.90). At the same reaction time, cysteine and temperature significantly affected the degradation efficiency of patulin in highly acidic conditions (p < 0.01). The rate constants (kT) for patulin degradation with cysteine (0.0036–0.3200 μg/L·min) were far more than those of treatments without cysteine (0.0012–0.1614 μg/L·min), and the activation energy (Ea = 43.89 kJ/mol) was far less than that of treatment without cysteine (61.74 kJ/mol). Increasing temperature could obviously improve the degradation efficiency of patulin, regardless of the presence of cysteine. Thus, both cysteine and high temperature decreased the stability of patulin in highly acidic conditions and improved its degradation efficiency, which could be applied to guide the detoxification of patulin by cysteine in the juice processing industry.

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Section: Discussionmentioning

confidence: 99%

Thermal Stability and Degradation Kinetics of Patulin in Highly Acidic Conditions: Impact of Cysteine

Diao

Zhang

et al. 2021

Toxins

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“…solvents, most of which have a negative environmental impact [14][15][16][17][18]. These extraction methods, including steam distillation, hydro distillation, and liquid-solvent extraction, require high temperatures, long processing times, and at times many extraction steps, limited extraction efficiency, safety issues, and environmental concerns regarding the use of toxic solvents [19][20][21][22][23][24].…”

Section: Phytochemical Classmentioning

confidence: 99%

Cold Plasma-Assisted Extraction of Phytochemicals: A Review

Heydari,

Carbone,

Gervasi

et al. 2023

Foods

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In recent years, there has been growing interest in bioactive plant compounds for their beneficial effects on health and for their potential in reducing the risk of developing certain diseases such as cancer, cardiovascular diseases, and neurodegenerative disorders. The extraction techniques conventionally used to obtain these phytocompounds, however, due to the use of toxic solvents and high temperatures, tend to be supplanted by innovative and unconventional techniques, in line with the demand for environmental and economic sustainability of new chemical processes. Among non-thermal technologies, cold plasma (CP), which has been successfully used for some years in the food industry as a treatment to improve food shelf life, seems to be one of the most promising solutions in green extraction processes. CP is characterized by its low environmental impact, low cost, and better extraction yield of phytochemicals, saving time, energy, and solvents compared with other classical extraction processes. In light of these considerations, this review aims to provide an overview of the potential and critical issues related to the use of CP in the extraction of phytochemicals, particularly polyphenols and essential oils. To review the current knowledge status and future insights of CP in this sector, a bibliometric study, providing quantitative information on the research activity based on the available published scientific literature, was carried out by the VOSviewer software (v. 1.6.18). Scientometric analysis has seen an increase in scientific studies over the past two years, underlining the growing interest of the scientific community in this natural substance extraction technique. The literature studies analyzed have shown that, in general, the use of CP was able to increase the yield of essential oil and polyphenols. Furthermore, the composition of the phytoextract obtained with CP would appear to be influenced by process parameters such as intensity (power and voltage), treatment time, and the working gas used. In general, the studies analyzed showed that the best yields in terms of total polyphenols and the antioxidant and antimicrobial properties of the phytoextracts were obtained using mild process conditions and nitrogen as the working gas. The use of CP as a non-conventional extraction technique is very recent, and further studies are needed to better understand the optimal process conditions to be adopted, and above all, in-depth studies are needed to better understand the mechanisms of plasma–plant matrix interaction to verify the possibility of any side reactions that could generate, in a highly oxidative environment, potentially hazardous substances, which would limit the exploitation of this technique at the industrial level.

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“…Therefore, a novel adsorbent with high PAT removal efficiency both in vivo and in vitro is in urgent need. Recently, cross-linked polymers demonstrated a great advantage in toxin-adsorption in vivo for its biocompatibility. ,, …”

Section: Introductionmentioning

confidence: 99%

“…12 Similarly, the potential of several yeast and lactic acid bacteria strains as PAT bio-degradants has also been revealed. 13,14 However, bio-sorbent can hardly achieve high adsorption capacity, while bio-degradants would bring in degradation products with unknown risks to human health. As a result of the mentioned facts, these detoxification methods fail to work when the contaminated food is already ingested into the human body.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, cross-linked polymers demonstrated a great advantage in toxin-adsorption in vivo for its biocompatibility. 11, 14,15 Lignin is an aromatic polymer composed of phenylpropane derivatives linked by ether bonds. As the second largest nature biopolymer resource, lignin is widely found in plant stems, fruit skins, shells, and cores, usually combined with hemicellulose, playing the role of supporting and protecting for plants.…”

Section: Introductionmentioning

confidence: 99%

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In Vitro and In Vivo Evaluation of Chlorogenic Acid-Encapsulated Lignin on Patulin Adsorption and Alleviation of Patulin-Induced Colonic Damage

Sun

Shi

Jing

et al. 2023

J. Agric. Food Chem.

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Patulin (PAT) is a water-soluble mycotoxin that causes digestive tract damage and liver and kidney function abnormalities. The current control approaches only reduce the amount of PAT in raw materials and food, which is difficult to remove once ingested in the body. In this study, lignin-based cross-linked particles loaded with chlorogenic acid were prepared, which intervened the liver and colon damage caused by PAT in mice. In the simulated digestion process in vitro, the accumulated adsorption capacity of the LB/CA-SH for PAT was 0.934 mg/g. LB/CA-SH intervention reversed the shortening of the colon length, alleviated the changes in the activities of antioxidant enzymes, and reduced the levels of oxidation markers protein carbonyl and malondialdehyde in the colon tissue of the model group. The absorption of sorbent alleviated the decrease of organ index and the abnormality of serum biochemical indexes (alanine aminotransferase, aspartate aminotransferase, urea nitrogen, and uric acid) caused by PAT. These results support the potential of using LB/CA-SH as a novel protective agent to reduce the toxicity of PAT.

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Detoxification of patulin from juice simulator and apple juice via cross-linked Se-chitosan/L-cysteine nanoparticles

Cited by 23 publications

References 47 publications

Thermal Stability and Degradation Kinetics of Patulin in Highly Acidic Conditions: Impact of Cysteine

Thermal Stability and Degradation Kinetics of Patulin in Highly Acidic Conditions: Impact of Cysteine

Cold Plasma-Assisted Extraction of Phytochemicals: A Review

In Vitro and In Vivo Evaluation of Chlorogenic Acid-Encapsulated Lignin on Patulin Adsorption and Alleviation of Patulin-Induced Colonic Damage

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