Detrimental effect of preservatives in eyedrops: implications for the treatment of glaucoma

Abstract

ABSTRACT.Antiglaucoma medications are often associated with ocular adverse reactions such as dry eye, and burning or stinging sensations. These undesirable effects may lead to treatment discontinuation and reduced quality of life in patients with glaucoma. Antiglaucoma medications usually contain benzalkonium chloride (BAK) as a preservative. Animal studies, in vitro studies and in vivo experiments have demonstrated various adverse effects of BAK. Clinical studies have also shown an increased incidence of adverse events with BAK and have demonstrated that the withdrawal of preservatives reduces these effects. Collectively, these data suggest that preservative-free antiglaucoma treatments have clinically relevant benefits for patients.

Sensitive and Real-Time Method for Evaluating Corneal Barrier Considering Tear Flow

“…Often underrecognized are the significant cytotoxic effects of preservatives associated with long-term therapy and especially use of multiple preserved drugs. [8][9][10] On the other hand, Baudouin suggests that dry eye and impaired tear film reduce the resistance of the cornea to the presence of toxic compounds. 10) However, there have been few reports to clarify the effect of tear flow on the corneal damage induced by BAC.…”

“…[8][9][10] On the other hand, Baudouin suggests that dry eye and impaired tear film reduce the resistance of the cornea to the presence of toxic compounds. 10) However, there have been few reports to clarify the effect of tear flow on the corneal damage induced by BAC. Therefore, we developed a new electrophysiological method mimicking tear flow in which precorneal solution was exchanged for buffer with a peristaltic pump at the rate of human tear flow.…”

Comparative Evaluation of Antihypertensive Drug’s Efficacy in Patients With Primary Glaucoma at Early and Advanced Stages

“…Надо отметить что, несмотря на отсутствие консерванта в препарате Тафлу-прост, при его применении наблюдалась гиперемия конъ-юнктивы [14,15,16,17,18]. Можно предположить, что ги-перемия связана с активным действием простагландинов, как медиаторов воспаления и аллергических реакций, независимо от наличия или отсутствия консервантов в составе препарата [19,20,21,22,23,24].…”

Analysis of treatment results in dry eye syndrome patients after phacoemulsification by preservative-free 0.3% sodium hyaluronate eye drops

“…Mean score before treatment was 19.6 ± 10.0. Positive disease dynamics after "Gilan Ultra Comfort" use is confirmed by a significant decrease of OSDI score index up to 12.3 ± 6.3. эпителия [3]. Будучи поверхностно активным ве-ществом, бензалкония хлорид вступает в химиче-скую реакцию с липидным слоем ПСП, разрушая его.…”