Detroit Dermatological Society

Sexton, George B.

doi:10.1001/archderm.1960.03730010150019

Cited by 2 publications

(1 citation statement)

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“…The current interest in the development of synthetic fuels from coal and oil shale has been accompanied by concern over potential adverse health effects which might occur as a result of production and use of these materials. Epidemiological studies indicate enhancement of skin cancer and precancers to be a major health concern associated with occupational exposure to synfuels (Costello, 1982;Purde and Rahu, 1979;Kipling and Waldron, 1976;Sexton, 1960). A variety of coal and shale derived oils have been shown to produce enhanced mutagenic effects in Salmonella (Selby et al, 1983) and Chinese hamster ovary cells (Strniste et al, 1982) in the presence of light, and since skin is exposed to environmental radiations, photomutagenic activity of synfuels may have an etiologic role in dermal neoplasia associated with these materials.…”

Section: Introductionmentioning

confidence: 99%

QUANTITATION OF THE PHOTOMUTAGENIC RESPONSE OF Salmonella TO AN EASTERN SHALE OIL AND FLUORESCENT LIGHT

Selby

Calkins

Enoch

1984

Photochem & Photobiology

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The dose-response relationship for photomutation (i.e. photosensitized mutation) hy a shalc-dcrived oil was examined. The Ames' Salmonella typhimuriurn tester strain TA98 was exposed to scvcral concentrations of an Eastern shale oil and UV-visible radiation from illumination-type fluorescent lamps. Reversion to histidine prototrophy and survival were assayed following various radiation doses.Reciprocity of shale oil concentration and radiation exposure over approximately 10-fold ranges of oil concentrations and radiation doses was observed with revertant numbers per plate, percent survival, and the induced frequency of revertants (revertants per survivor). The relationship between mutation frequency and the product (shale oil concentration times radiation exposure) fit well with either a linear model or a power law model in which the frequency of induced mutations was described by the product dose raised to the 1.26th power. Similar dose-response relationships provide potential criteria for comparing potency of photomutagenic substances, comparisons that may be valuable towards asscasing, and perhaps modifying, risks imposed by human exposure to synthetic fuels.

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Section: Introductionmentioning

confidence: 99%