Deutscher Konsensus 2013 zur immungenetischen Spenderauswahl für die allogene Stammzelltransplantation

Müller, Ch.; Mytilineos, Joannis; Ottinger, Hellmut; Arnold, Renate; Bader, Peter; Beelen, Dietrich W.; Bornhäuser, Martin; Dreger, Peter; Eiermann, Thomas; Einsele, Hermann; Faé, I.; Fischer, G.; Füssel, M.; Holler, Ernst; Holzberger, G.; Horn, Peter A.; Kröger, N.; Lindemann, Monika; Seidl, Christof; Spriewald, Bernd M.; Süsal, C.; Blasczyk, Rainer; Finke, Jürgen

doi:10.1055/s-0034-1383141

Cited by 6 publications

(2 citation statements)

References 37 publications

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“…Only six depend on variations outside all exons and are rarely considered. However, the identification of null alleles defined in non‐ARD exons is handled inconsistently because of the lack of an efficient general typing strategy . Therefore, the AFs of those null alleles are most likely underestimated.…”

Section: Discussionmentioning

confidence: 99%

Common and well‐documented HLA alleles of German stem cell donors by haplotype frequency estimation

Eberhard

Schmidt

Mytilineos

et al. 2018

HLA

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We present a catalog of common and well‐documented (CWD) alleles of the German population for the six HLA loci A, B, C, DRB1, DQB1, and DPB1. This study is based on a sample of over 5 million volunteer adult hematopoietic stem cell donors from the 26 German donor centers. To establish the catalog, allele and haplotype frequencies were estimated with a validated implementation of the expectation‐maximization algorithm. CWD criteria similar to existing CWD catalogs were applied in order to be able to put our findings into the context of relevant existing references. Overall, 2155 HLA‐A, ‐B, ‐C, ‐DRB1, ‐DQB1, and ‐DPB1 alleles were identified as CWD in the German donor population representing about 20% of the HLA alleles at two‐field resolution in the IPD‐IMGT/HLA Database release v3.25.0 from July 2016 for these six loci. We found a substantial concordance of CWD alleles between the three catalogs and showed the contribution of the German donor population to the CWD alleles domain. In conclusion, the definition of CWD criteria that allow interoperability, scalability, and flexibility will be crucial for the development of a worldwide CWD catalog.

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Section: Discussionmentioning

confidence: 99%

Common and well‐documented HLA alleles of German stem cell donors by haplotype frequency estimation

Eberhard

Schmidt

Mytilineos

et al. 2018

HLA

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“…Historically, the HMAs were developed independently within each donor registry as a part of a highly specialized individual IT infrastructure . Subsequently, HMAs have been developed further to encompass the evolution of the serological and molecular HLA nomenclature and also because of the growing scientific understanding of the clinical matching requirements . In particular, the HLA typing resolution required, the number of HLA loci to be considered and the number of donors typed incompletely or at insufficient resolution have promoted a heterogeneous range of matching philosophies.…”

Section: Introductionmentioning

confidence: 99%

A comparative reference study for the validation of HLA‐matching algorithms in the search for allogeneic hematopoietic stem cell donors and cord blood units

Bochtler

Gragert

Patel

et al. 2016

HLA

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The accuracy of human leukocyte antigen (HLA)‐matching algorithms is a prerequisite for the correct and efficient identification of optimal unrelated donors for patients requiring hematopoietic stem cell transplantation. The goal of this World Marrow Donor Association study was to validate established matching algorithms from different international donor registries by challenging them with simulated input data and subsequently comparing the output. This experiment addressed three specific aspects of HLA matching using different data sets for tasks of increasing complexity. The first two tasks targeted the traditional matching approach identifying discrepancies between patient and donor HLA genotypes by counting antigen and allele differences. Contemporary matching procedures predicting the probability for HLA identity using haplotype frequencies were addressed by the third task. In each task, the identified disparities between the results of the participating computer programs were analyzed, classified and quantified. This study led to a deep understanding of the algorithms participating and finally produced virtually identical results. The unresolved discrepancies total to less than 1%, 4% and 2% for the three tasks and are mostly because of individual decisions in the design of the programs. Based on these findings, reference results for the three input data sets were compiled that can be used to validate future matching algorithms and thus improve the quality of the global donor search process.

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Naturwissenschaftliche Grundlagen im Kontext einer klinischen Anwendung von humanen induzierten pluripotenten Stammzellen

Neubauer¹,

Bur

Meiser

et al. 2019

Veröffentlichungen Des Instituts Für Deutsches, Europäisches Und Internationales Medizinrecht, Gesundheitsrecht Und Bioethik De

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Deutscher Konsensus 2013 zur immungenetischen Spenderauswahl für die allogene Stammzelltransplantation

Cited by 6 publications

References 37 publications

Common and well‐documented HLA alleles of German stem cell donors by haplotype frequency estimation

Common and well‐documented HLA alleles of German stem cell donors by haplotype frequency estimation

A comparative reference study for the validation of HLA‐matching algorithms in the search for allogeneic hematopoietic stem cell donors and cord blood units

Naturwissenschaftliche Grundlagen im Kontext einer klinischen Anwendung von humanen induzierten pluripotenten Stammzellen

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