Deux tumeurs rares du sein

Abrikossof’s Tumor: Report of a Case

“…There are few cases of malignant GCTs of the breast in the literature (1% -2% of GCTs of the breast). Malignant GCTs are often larger and faster growing, and the occurrence of metastases remains one of the most important criteria for defining malignancy [10]. Gomard-Menesson et al described a case of a benign granular cell tumor that undergoes malignant transformation after a 7-year free interval [4].…”

“…The most common characteristics are a solid, heterogeneous image, with deep development, vascularization, especially in the periphery [10]. Magnetic resonance imaging with gadolinium injection can help differentiate between malignant and benign GCTs.…”

“…Malignant GCTs rapidly take up the contrast medium in the first minute after injection, with a plateau as early as the second minute because of the greater vascularity. Contrast with a peripheral corona is frequently found and may suggest malignancy [10].…”

“…The immunohistochemical study confirms the diagnosis. The tumor cells are positive for neurogenic markers (PS100 and NSE) [10].…”

“…However, the evolutionary follow-up can be enmeshed of local recurrence or secondary metastatic localization particularly pulmonary or bone. The complementary and systematic analysis of a cell proliferation index (Ki67) could be a useful aid to define the presence of this evolutionary turning point [2] [4] [8] [10].…”