Developed countries should use inactivated polio vaccine for the prevention of poliomyelitis

Parenteral Immunization and Protection from Mucosal Infection

“…Indeed, experimental evidence exists to support this hypothesis (reviewed in Murdin et al, 1996). The recent introduction of a combined (IPV-OPV) approach offers the potential to obtain the maximum protection against paralytic disease and community spread of wild-type virus (Plotkin, 1997). This said, OPV is far superior to the inactivated parenteral vaccine in preventing viral shedding from the gastrointestinal tract; thus, it remains the primary approach to providing protection from polio infection (Hird and Grassly, 2012).…”