Developing a comprehensive solution aimed to disrupt LARS1/RagD protein-protein interaction

Raevsky, Alexey V.; Kovalenko, Oksana; Elijah, Bulgakov; Sharifi, Mohsen; Volochnyuk, Dmityi; Tukalo, M. A.

doi:10.1080/07391102.2023.2194996

Journal of Biomolecular Structure and Dynamics

2023

DOI: 10.1080/07391102.2023.2194996

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Developing a comprehensive solution aimed to disrupt LARS1/RagD protein-protein interaction

Alexey V. Raevsky

Oksana Kovalenko

Bulgakov Elijah

et al.

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2024

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Branched-chain amino acids: physico-chemical properties, industrial synthesis and role in signaling, metabolism and energy production

Reifenberg,

Zimmer

2024

Amino Acids

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Branched-chain amino acids (BCAAs)—leucine (Leu), isoleucine (Ile), and valine (Val)—are essential nutrients with significant roles in protein synthesis, metabolic regulation, and energy production. This review paper offers a detailed examination of the physico-chemical properties of BCAAs, their industrial synthesis, and their critical functions in various biological processes. The unique isomerism of BCAAs is presented, focusing on analytical challenges in their separation and quantification as well as their solubility characteristics, which are crucial for formulation and purification applications. The industrial synthesis of BCAAs, particularly using bacterial strains like Corynebacterium glutamicum, is explored, alongside methods such as genetic engineering aimed at enhancing production, detailing the enzymatic processes and specific precursors. The dietary uptake, distribution, and catabolism of BCAAs are reviewed as fundamental components of their physiological functions. Ultimately, their multifaceted impact on signaling pathways, immune function, and disease progression is discussed, providing insights into their profound influence on muscle protein synthesis and metabolic health. This comprehensive analysis serves as a resource for understanding both the basic and complex roles of BCAAs in biological systems and their industrial application.

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Branched-chain amino acids: physico-chemical properties, industrial synthesis and role in signaling, metabolism and energy production

Reifenberg,

Zimmer

2024

Amino Acids

View full text Add to dashboard Cite

show abstract

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Developing a comprehensive solution aimed to disrupt LARS1/RagD protein-protein interaction

Cited by 1 publication

References 42 publications

Branched-chain amino acids: physico-chemical properties, industrial synthesis and role in signaling, metabolism and energy production

Branched-chain amino acids: physico-chemical properties, industrial synthesis and role in signaling, metabolism and energy production

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