In general, the manufacturing industry relies more on machine-based processes. However, in certain activities, human labor is still needed due to the limitations of the machine function, as humans are faster than the machine. However, the activities using human muscle power are at risk of postural stress and early work fatigue. Work fatigue will affect work performance and productivity. The Standard Operating Procedures (SOP), which do not consider work attitude, will result in inconvenience at work and complaints on body parts and decreased performance. Besides, it also causes the inability to meet production targets so that employees cannot reach the maximum wage, and the company suffers losses. The redesign of the Standard Operating Procedures (SOP) is needed to make people as the center of all improvement activities. The design used in this study was treatment by subject design. The results showed that there were differences (p <0.05) between pre- and post-intervention results, Decreased postural stress complaints (moment of compressive force) in posture 1 (7.31%), posture 2 (23.09%), and posture 3 (4.74%). In comparison, the reduction of work fatigue was obtained from 81.26±10.85 to 70.87±3.68 (12.78%). After the implementation of ergonomic-based SOPs, there was an increase in employee income by 25.23% or (IDR 2,068,091/month) and an increase in company profits (IDR 51,702,286/month). The implementation of ergonomic-based SOPs was able to reduce postural stress, fatigue, and to increase employee income and company profits.