Hot working environment not only affects work efficiency, but also poses a potential threat to the physical and mental health of staff. The current common method for dealing with high temperatures is spray-only or ventilation-only. To investigate the impact of different spray and ventilation modes on indoor high-temperature environments, this study examined their effects on indoor environmental parameters, average skin temperature, and psychological indicators. By establishing an experimental platform for high-temperature thermal environments, a spray ventilation cooling system was implemented, and its cooling efficacy in the indoor thermal environment was analyzed. The environmental classification of the high-temperature working environment under experimental conditions is provided based on the experimental data. A comparison and analysis of environmental parameters and physiological and psychological indicators between moderate and high-temperature environments were conducted. The combination of spray and ventilation modes resulted in a 5.3 °C reduction in air temperature, a 24.1% increase in average relative humidity, and a 3.3 °C reduction in average Wet-bulb Globe Temperature (WBGT). The cooling effect was increased by 2.3 °C and the average relative humidity was increased by 10.8% compared to spray-only and ventilation-only modes. In spray and ventilation mode, when the spray volume is increased by 15 mL/min, the air temperature is reduced by 8.2 °C, the average relative humidity is increased by 31.9%, and the average WBGT is reduced by 5.1 °C. This study has guiding significance for finding a reasonable cooling scheme to cope with indoor high-temperature environments.