Spiritual Well-Being (SiWB) is a condition where individuals can reflect a positive feeling, action, and form of thinking related to oneself, others and the environment as well as to the transcendent (God). The purpose of this paper is to determine the impact of spiritual-based psychological interventions in improving the well-being of Spiritual Well-Being. The research method used is a systematic literature review. The source of data in this study is based on journals, and articles related to spiritual intervention in cancer patients. The focus of the literature search in the Literature Review uses the Research Engine Databases, namely Google Scholar, PubMed, Research gate, and Academia. Spiritual Well-Being (SiWB). Based on the results of 8 previous studies that were reviewed and analyzed, it was found that the process of spiritual-based psychological intervention can play a role in fulfilling psychological conditions spiritually. Spiritual-based psychological interventions can also increase the quality of life, hope, and meaning in life which can provide hope, calm, happiness, and awareness in individuals.