Assessing areas prone to flash floods is crucial for effective disaster management and mitigation. This study proposes a framework for mapping flood-prone areas by integrating geographic information system (GIS), remote sensing data, and multi-criteria decision-making (MCDM) techniques. The hybrid MCDM model combines the decision-making trial and evaluation laboratory (DEMATEL) with GIS-based analytic network process (ANP) to evaluate flood vulnerability in Golestan province, Iran. Fourteen criteria related to flood potential, including elevation, slope, aspect, vegetation density, soil moisture, flow direction, river distance, rainfall and runoff, flow time, geomorphology, drainage density, soil type, lithology, and land use, were considered. In areas where official data was lacking, a questionnaire was administered to gather information from 15 specialists, experts, and 20 local managers. The relationships between criteria were analyzed using the DEMATEL method, and their weights were determined using the ANP method. Topography was found to have the greatest impact on flood risk, followed by the type of surface and vegetation cover. Hydrographic, soil and geology, climatic also influence flooding in the region. The study identified the northern and central parts of the study area being at higher risk of flooding compared to the southern part. Based on the flood intensity map, 68 villages (50% of all villages in the Qarasu watershed) with a population of approximately 83,595 were identified as at risk of flooding. The proposed GIS-DANP model provides a valuable tool for flood management and decision-making, aiding in risk reduction and minimizing casualties.