Developing an innovative 3D printing platform for production of personalised medicines in a hospital for the OPERA clinical trial

Denis, Lucas; Jørgensen, Anna Kirstine; Do, Bernard; Vaz-Luis, Inès; Pistilli, Barbara; Rieutord, André; Basit, Abdul W; Goyanes, Alvaro; Annereau, Maxime

doi:10.1016/j.ijpharm.2024.124306

International Journal of Pharmaceutics

2024

DOI: 10.1016/j.ijpharm.2024.124306

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Developing an innovative 3D printing platform for production of personalised medicines in a hospital for the OPERA clinical trial

Lucas Denis,

Anna Kirstine Jørgensen,

Bernard Do

et al.

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Cited by 9 publications

References 31 publications

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Volumetric printing and non-destructive drug quantification of water-soluble supramolecular hydrogels

Ong,

Jørgensen,

Zhu

et al. 2024

Drug Deliv. and Transl. Res.

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Vat photopolymerisation 3D printing is being actively explored for manufacturing personalised medicines due to its high dimensional accuracy and lack of heat application. However, several challenges have hindered its clinical translation, including the inadequate printing speeds, the lack of resins that give soluble matrices, and the need for non-destructive quality control measures. In this study, for the first time, a rapid approach to producing water-soluble vat photopolymerised matrices and a means of non-destructively verifying their drug content were investigated. Volumetric printing, a novel form of vat photopolymerisation, was used to fabricate personalised warfarin-loaded 3D-printed tablets (printlets). Eight different formulations containing varying amounts of warfarin (0.5–6.0% w/w) were used to print two different sized torus-shaped printlets within 6.5 to 11.1 s. Nuclear magnetic resonance (NMR) spectroscopy revealed the presence of only trace amounts of unreacted acrylate monomers, suggesting that the photopolymerisation reaction had occurred to near completion. All printlets completely solubilised and released their entire drug load within 2.5 to 7 h. NIR spectroscopy (NIRS) was used to non-destructively verify the dose of warfarin loaded into the vat photopolymerised printlets. The partial least square regression model built showed strong linearity (R2 = 0.980), and high accuracy in predicting the drug loading of the test sample (RMSEP = 0.205%). Therefore, this study advances pharmaceutical vat photopolymerisation by demonstrating the feasibility of producing water-soluble printlets via volumetric printing and quantifying the drug load of vat photopolymerised printlets with NIRS. Graphical abstract

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Volumetric printing and non-destructive drug quantification of water-soluble supramolecular hydrogels

Ong,

Jørgensen,

Zhu

et al. 2024

Drug Deliv. and Transl. Res.

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show abstract

Extrusion-based 3D printing for development of complex capsular systems for advanced drug delivery

Algahtani,

Ahmad,

Mohammed

et al. 2024

International Journal of Pharmaceutics

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Optimising 3D printed medications for rare diseases: In-line mass uniformity testing in direct powder extrusion 3D printing

Mora-Castaño,

Rodríguez-Pombo,

Carou-Senra

et al. 2025

International Journal of Pharmaceutics

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Developing an innovative 3D printing platform for production of personalised medicines in a hospital for the OPERA clinical trial

Cited by 9 publications

References 31 publications

Volumetric printing and non-destructive drug quantification of water-soluble supramolecular hydrogels

Volumetric printing and non-destructive drug quantification of water-soluble supramolecular hydrogels

Extrusion-based 3D printing for development of complex capsular systems for advanced drug delivery

Optimising 3D printed medications for rare diseases: In-line mass uniformity testing in direct powder extrusion 3D printing

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