In this article, we articulate an innovative framework, <i>manywheres</i>, and argue that it can advance the work of fostering youth-led change and progressive world-making. We first root psychological and development science in an applied framework of developing more just, harmonious, and tolerant social worlds. Then, we introduce <i>manywheres</i>, a guiding framework of propositions of attending to the complexity and nuance of meaning-making across individuals without becoming lost in nihilism, relativism, or ethnocentric views of social justice. This leads to the construction of a more holistic developmental lens considering the age-related, contextual, and internal factors that shape meaning-making individual trajectories and societal outcomes. <i>Manywheres</i> can thus structure thinking and research with an end goal of understanding the diversity of young people’s engagement, activism, and disconnection. We end with mapping a research agenda applying these ideals, incorporating the methodological approaches that can be taken, concrete examples, and implications that can be applied to salient social issues.