Developing mechanically robust, triazole-zwitterionic hydrogels to mitigate foreign body response (FBR) for islet encapsulation

Liu, Qingsheng; Chiu, Alan; Wang, Long‐Hai; An, Duo; Li, Wenchen; Chen, Esther Y.; Zhang, Yu; Pardo, Yehudah; McDonough, Sean P.; Liu, Lingyun; Liu, Wendy F.; Chen, Jing; Ma, Minglin

doi:10.1016/j.biomaterials.2019.119640

Cited by 72 publications

(77 citation statements)

References 50 publications

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“…Such hydration barriers can prevent the initial nonspecific protein adsorption onto superhydrophilic surfaces, which has been proven to prevent the initial step of planktonic bacterial attachment. 57 Apart from well-known hydrophilic polymers, such as hyaluronic acid (HA), poly (ethylene glycol) (PEG), and peptides, zwitterionic polymers, such as polycarboxybetaine (PCB), 58–60 polysulfobetaine (PSB), 61–63 poly (quaternized triazole carboxybetaine acrylamide) [P(qTR-CB)], 64 and poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), appear to have superior antifouling properties due to their excellent water-binding capability and thus superhydrophilicity. 65,66 Traditional hydrophilic surfaces, represented by PEG and its derivatives, are achieved by hydrogen bonds between surfaces and water molecules.…”

Section: Hydrogels Against Infectionsmentioning

confidence: 99%

Functional hydrogels for diabetic wound management

et al. 2021

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Diabetic wounds often have a slow healing process and become easily infected owing to hyperglycemia in wound beds. Once planktonic bacterial cells develop into biofilms, the diabetic wound becomes more resistant to treatment. Although it remains challenging to accelerate healing in a diabetic wound due to complex pathology, including bacterial infection, high reactive oxygen species, chronic inflammation, and impaired angiogenesis, the development of multifunctional hydrogels is a promising strategy. Multiple functions, including antibacterial, pro-angiogenesis, and overall pro-healing, are high priorities. Here, design strategies, mechanisms of action, performance, and application of functional hydrogels are systematically discussed. The unique properties of hydrogels, including bactericidal and wound healing promotive effects, are reviewed. Considering the clinical need, stimuli-responsive and multifunctional hydrogels that can accelerate diabetic wound healing are likely to form an important part of future diabetic wound management.

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Section: Hydrogels Against Infectionsmentioning

confidence: 99%

Functional hydrogels for diabetic wound management

et al. 2021

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“…IT has been the prototypical model to test cellular encapsulation technologies, since islets are amenable to macro and microencapsulation 58 . These strategies have advanced greatly in the last decades, with low‐fouling, “immune friendly” biomaterials, 93 and composite bioscaffolds now allowing localized immunosuppression/immunoregulation at the implantation site, 82,94 showing promising results in terms of graft acceptance and long‐term diabetes reversal in preclinical models. These strategies are compatible with stem‐cell therapies 95–97 and xenotransplantation 58 .…”

Section: Challenges and Potential Solutionsmentioning

confidence: 99%

Clinical islet transplantation: Current progress and new frontiers

Marfil‐Garza

Shapiro

Kin

2021

J Hepato Biliary Pancreat

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Islet transplantation (IT) is now a robust treatment for selected patients with type 1 diabetes suffering from recurrent hypoglycemia and impaired awareness of hypoglycemia. A global soar of clinical islet transplant programs attests to the commitment of many institutions and researchers to advance IT as a potential cure for this devastating disease. However, many challenges limiting the widespread applicability of clinical IT remain. In this review, we will touch on the milestones in the history of IT and its path to clinical success, discuss the current challenges around IT, propose some possible solutions, and elaborate on the frontiers envisioned in the future of clinical IT.

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“…269,270 For example, the incorporation of triazole created a hydrogel surface to resist the FBR by reducing macrophage recognition and fibrosis. 271 Moreover, Wang et al engineered a photoinitiated HA-based hydrogel with tunable macrophage adhesive sites. This composite hydrogel could temporally activate avb3-integrin expressions on macrophages and consequently promote antiinflammatory macrophage polarization to achieve the mitigation of the FBR.…”

Section: Stem Cell Deliverymentioning

confidence: 99%

Composition and Mechanism of Three-Dimensional Hydrogel System in Regulating Stem Cell Fate

Huang

2020

Tissue Engineering Part B: Reviews

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Three-dimensional (3D) hydrogel systems integrating different types of stem cells and scaffolding biomaterials have an important application in tissue engineering. The biomimetic hydrogels that pattern cell suspensions within 3D configurations of biomaterial networks allow for the transport of bioactive factors and mimic the stem cell niche in vivo, thereby supporting the proliferation and differentiation of stem cells. The composition of a 3D hydrogel system determines the physical and chemical characteristics that regulate stem cell function through a biological mechanism. Here, we discuss the natural and synthetic hydrogel compositions that have been employed in 3D scaffolding, focusing on their characteristics, fabrication, biocompatibility, and regulatory effects on stem cell proliferation and differentiation. We also discuss the regulatory mechanisms of cell-matrix interaction and cell-cell interaction in stem cell activities in various types of 3D hydrogel systems. Understanding hydrogel compositions and their cellular mechanisms can yield insights into how scaffolding biomaterials and stem cells interact and can lead to the development of novel hydrogel systems of stem cells in tissue engineering and stem cell-based regenerative medicine.

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Developing mechanically robust, triazole-zwitterionic hydrogels to mitigate foreign body response (FBR) for islet encapsulation

Cited by 72 publications

References 50 publications

Functional hydrogels for diabetic wound management

Functional hydrogels for diabetic wound management

Clinical islet transplantation: Current progress and new frontiers

Composition and Mechanism of Three-Dimensional Hydrogel System in Regulating Stem Cell Fate

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