Developing optical up-conversion process via embedded silver nanostructures

Hajjiah, Ali; Ibrahim, Roanne; Ibrahim, N.; Gamal, Mohammed; Elrafei, Sara A.; Shehata, Nader; Kandas, Ishac

doi:10.1016/j.jlumin.2021.118717

Cited by 3 publications

(2 citation statements)

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“…Lanthanide-doped upconversion nanoparticles (UCNPs) are a nonlinear luminescent material absorbing a few low-energy near-infrared photons and emitting high-energy photons, which have numerous highlights such as large anti-Stokes shifts, sharp emission bandwidth, favorable photostability, high luminescence efficiency, near-free background interference, long luminescence life, and strong photobleaching resistance as a critical nanolabel material. − In the past few years, UCNPs have been widely used in drug delivery, biological imaging, and biosensors, wherein hexagonal phase NaYF 4 has been considered as a promising class of host lattices on account of the ultralow phonon energy, codoped with Yb 3+ and other rare-earth ions as sensitizers or activators for maximizing the energy availability and tuning the emission wavelengths. , …”

Section: Introductionmentioning

confidence: 99%

“…28−30 In the past few years, UCNPs have been widely used in drug delivery, 31 biological imaging, 32 and biosensors, 33 wherein hexagonal phase NaYF 4 has been considered as a promising class of host lattices on account of the ultralow phonon energy, codoped with Yb 3+ and other rare-earth ions as sensitizers or activators for maximizing the energy availability and tuning the emission wavelengths. 34,35 Circulating miRNAs are thought as a promising biomarker for early diagnosis and prognostic of cancers because of their key role in gene expression and the noninvasive and costeffective characteristics for detection, which generally consist of 17−25 bases and are able to interreact with complementary DNA oligonucleotides. 36,37 Research suggests that upregulation or downregulation of some specific miRNAs is related to triple-negative breast cancer (TNBC), 38,39 which is a kind of heterogeneous tumor with poor treatment and prognosis beyond the biodetection associated with receptor expression.…”

Section: ■ Introductionmentioning

confidence: 99%

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Multiple miRNA Detection through a Suspended Microbead Array Encoded by Triple-Color Upconversion Luminescent Nanotags via Bi-Beam Splitter Hybrid-Multitrap Optical Tweezers

Yu,

Jia,

et al. 2023

Anal. Chem.

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In recent years, optical tweezers have become a novel tool for biodetection, and to improve the inefficiency of a single trap, the development of multitraps is required. Herein, we constructed a set of hybrid multitrap optical tweezers with the balance of stability and flexibility by the combination of two different beam splitters, a diffraction optical element (DOE) and galvano mirrors (GMs), to capture polystyrene (PS) microbeads in aqueous solutions to create an 18-trap suspended array. A sandwich hybridization strategy of DNA-miRNA-DNA was adopted to detect three kinds of target miRNAs associated with triple negative breast cancer (TNBC), in which different upconversion nanoparticles (UCNPs) with red, green, and blue emissions were applied as luminescent tags to encode the carrier PS microbeads to further indicate the levels of the targets. With encoded luminescent microbeads imaged by a three-channel microscopic system, the biodetection displayed high sensitivity with low limits of detection (LODs) of 0.27, 0.32, and 0.33 fM and exceptional linear ranges of 0.5 fM to 1 nM, 0.7 fM to 1 nM, and 1 fM to 1 nM for miR-343-3p, miR-155, and miR-199a-5p, respectively. In addition, this bead-based assay method was demonstrated to have the potential for being applied in patients’ serum by satisfactory standard addition recovery experiment results.

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