Aiming at the different levels of college English education, and finding problems and countermeasures in time, this paper puts forward a research on college English education reform under the cultural differences between China and foreign countries. Exploring the cultural background behind the learning of English knowledge, China and foreign countries have formed two completely different cultural forms, resulting in differences in language communication, behavioral expression, way of thinking, and living habits between China and foreign countries. Advocate and motivate students to learn Chinese and Western cultures, cultivate students’ cross-cultural awareness, actively explore English language and culture, and apply modern teaching methods to college English teaching. Mining high-quality parameters to quickly obtain target data, set reasonable control factors, and calculate the information gain of data attributes. Using differentiated information reorganization, a distributed recursive statistical analysis model of students’ English grades was established, the characteristic parameters of grade differences were analyzed, the optimal lag order was selected for the prediction error index, and the co-integration relationship of test variables of students’ grade differences was realized. The results of the study show that the classes that have undergone reformed education combined with Chinese and foreign countries have significantly improved their college English, with an average score of over 89.