Developing the Optimal Synthetic Schem for the Potential Nootropic Drug GZK-111, N-Phenylacetylglycyl-L-Proline Ethyl Ester

Optimization of the Synthesis of New Antibacterial Compounds with Tris(1-Alkylindol-3-YL)Methylium Fragments

“…The main goal of the present work was to find the optimal synthetic method for the above type of compounds to produce significant amounts of them for further in-depth studies [16,17]. The previously developed synthetic scheme (Scheme 1) [5] had several drawbacks, e.g., several chemical transformation steps; use of expensive indoline (I) and dibromomaleimide (II); labor-intensive isolation of interme-diates; column chromatography in each synthetic step; and low product yields in steps for formylation and substitution of Br atoms by amines.…”