Inspired by the principles of Systems Theory, this study explores the modern workplace, as a multifaceted and ever-evolving organisation system in which mental wellbeing, stress, resilience, counterproductive work behavior, and substance abuse are interrelated, impacting one another via feedback loops. Thus, our aim was to evaluate a management framework that addresses how these constructs are connected as well as how to manage them within the workplace. A survey tool with standardized questionnaires was used to collect data from 446 employees. The measurement model demonstrated construct reliability and validity, whereas the structural model examined the strength of linkages. Higher resilience reduced stress, boosting mental wellbeing which acted as a stabilizing influence against substance abuse and counterproductive work behavior. This study highlights the complicated interplay between these variables and emphasizes the critical significance of mental wellbeing in maintaining balance for organizational success.