Development and analysis of a novel loading technique for FDM 3D printed systems: Microwave-assisted impregnation of gastro-retentive PVA capsular devices

Saviano, Marialuisa; Benjamin, James B.; Penny, Matthew R.; Ishaq, Ahtsham; Muwaffak, Zaid; Falcone, Giovanni; Russo, Paola; Hilton, Stephen T.

doi:10.1016/j.ijpharm.2021.121386

Cited by 10 publications

(5 citation statements)

References 28 publications

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“…Specifically, the simplicity and low cost of FDM 3DP has led to the general view that it may be the technology to be clinically adopted to produce personalized medicines. Enthusiasm towards FDM 3DP amongst pharmaceutical researchers has been demonstrated by its use to manufacture a range of drug delivery devices, including 3D printed tablets (Printlets) ( Bogdahn et al, 2021 ; Figueiredo et al, 2022 ; Isreb et al, 2019 ; Melocchi et al, 2021 ; Oladeji et al, 2022 ; Pereira et al, 2020 ; Shi et al, 2021 ; Tranová et al, 2022 ; Windolf et al, 2022 ), gastro-retentive tablets ( Zhao et al, 2022 ), microneedles ( Wu et al, 2021 ), and patient-specific devices ( Arany et al, 2021 ; Carlier et al, 2021 ; Eleftheriadis and Fatouros, 2021 ; Eleftheriadis et al, 2020 ; Haddow et al, 2021 ; Liang et al, 2018 ; Saviano et al, 2022 ). While interest in pharmaceutical 3DP continues to grow, with pharmaceutical companies such as Aprecia and Triastek investing in the technology, progress is arguably hampered by the empirical process of formulation development ( Elbadawi et al, 2021b ; Seoane-Viaño et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Accelerating 3D printing of pharmaceutical products using machine learning

Ong

Castro

Gaisford

et al. 2022

International Journal of Pharmaceutics: X

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Section: Introductionmentioning

confidence: 99%

Accelerating 3D printing of pharmaceutical products using machine learning

Ong

Castro

Gaisford

et al. 2022

International Journal of Pharmaceutics: X

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“…This research evaluated the impact of this process on the drug loading efficiency and stability and thermal and chemical characteristics of the drug release profile and printing morphology. The results demonstrated that drug impregnation into drug delivery devices is highly efficient, suggesting that this approach is an alternative technique for personalized drug delivery [51].…”

Section: Polyvinyl Alcohol (Pva)mentioning

confidence: 99%

“…Due to its very low melting temperature (approximately 70 • C) and glass transition temperature (approximately 40 • C), PEG is frequently used as an additive (plasticizer) to improve the processability of other polymers [51], such as PCL, PLA, PLGA, PU, and PVA.…”

Section: Polyethylene Glycolmentioning

confidence: 99%

An Approach to 3D Printing Techniques, Polymer Materials, and Their Applications in the Production of Drug Delivery Systems

Cardoso,

Araújo

2024

Compounds

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Three-dimensional printing (3DP) technologies are characterized as a set of innovative manufacturing techniques that allow for the creation of complex and/or personalized three-dimensional physical objects on the work surface of a 3D printing machine (based on the computer-aided design (CAD) project designs of these parts). Three-dimensional printing techniques are widely used in various areas of knowledge, such as education, engineering, and biomedicine. Polymeric materials are widely used for these applications, mainly due to their desirable workability during part manufacturing, compatibility with other chemical materials, the wide range of polymers with different physical and chemical characteristics, and the possibility for recycling. The development of polymeric drug delivery systems (DDSs) by 3D printing is currently an active field of research, both in academia and industry, given the potential of this technique for medical purposes. In this context, this work reviews potential polymers for the production of drug delivery systems via 3D printing techniques. The demonstrations of the main 3DP techniques used for drug delivery applications include their working principles and advantages and how the technologies develop the final product. In addition, potential synthetic and natural polymers that are currently used in 3DP drug delivery devices are presented and discussed based on recent scientific studies.

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“…The object is built up layer-by-layer using a variety of materials such as plastic, metal, or resin [2,3]. 3D printing can be used to create a wide range of objects, from small figurines to complex mechanical parts [4]. This technology has become increasingly popular in recent years and is used in industries such as manufacturing, healthcare, and architecture [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Mathematical Modelling of Fused Deposition Modeling (FDM) 3D Printing of Poly Vinyl Alcohol Parts through Statistical Design of Experiments Approach

Moradi,

Karamimoghadam,

Meiabadi

et al. 2023

Mathematics

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This paper explores the 3D printing of poly vinyl alcohol (PVA) using the fused deposition modeling (FDM) process by conducting statistical modeling and optimization. This study focuses on varying the infill percentage (10–50%) and patterns (Cubic, Gyroid, tri-hexagon and triangle, Grid) as input parameters for the response surface methodology (DOE) while measuring modulus, elongation at break, and weight as experimental responses. To determine the optimal parameters, a regression equation analysis was conducted to identify the most significant parameters. The results indicate that both input parameters significantly impact the output responses. The Design Expert software was utilized to create surface and residual plots, and the interaction between the two input parameters shows that increasing the infill percentage (IP) leads to printing heavier samples, while the patterns do not affect the weight of the parts due to close printing structures. On the contrary, the discrepancy between the predicted and actual responses for the optimal samples is below 15%. This level of error is deemed acceptable for the DOE experiments.

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Development and analysis of a novel loading technique for FDM 3D printed systems: Microwave-assisted impregnation of gastro-retentive PVA capsular devices

Cited by 10 publications

References 28 publications

Accelerating 3D printing of pharmaceutical products using machine learning

Accelerating 3D printing of pharmaceutical products using machine learning

An Approach to 3D Printing Techniques, Polymer Materials, and Their Applications in the Production of Drug Delivery Systems

Mathematical Modelling of Fused Deposition Modeling (FDM) 3D Printing of Poly Vinyl Alcohol Parts through Statistical Design of Experiments Approach

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