The study and development of miniature refrigeration and climate conditioning systems based on vapor compression for small-scale applications have received wide interest in recent years due to their advantages compared with other available technologies, both active and passive. This paper identifies different applications and areas of opportunity, including electronic components and personal cooling, where small-scale vapor compression refrigeration systems are anticipated to play a key role in technological development. This paper presents the current state of the art, including applications, component designs, operating conditions, experiments, published results, etc. to describe the current status of small-scale vapor compression refrigeration and illustrate a perspective for the future of this technology.