Development and analysis of multi-layer scaffolds for tissue engineering

Papenburg, Bernke J.; Li, Jun; Higuera, Gustavo A.; Barradas, Ana; Boer, Jan de; Blitterswijk, Clemens A. van; Weßling, Matthias; Stamatialis, Dimitrios

doi:10.1016/j.biomaterials.2009.07.057

Cited by 111 publications

(91 citation statements)

References 21 publications

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“…[291]), and co-polymerization [44]. Three dimensional porous scaffolds of PLA have been created for culturing different cell types, using in cell based gene therapy for cardiovascular diseases; muscle tissues, bone and cartilage regeneration and other treatments of cardiovascular, neurological, and orthopedic conditions [292][293][294]. Another two studies have reported osteogenic stem cells seeded on scaffolds of this material and implanted in bone defects or subcutaneously for recapitulating both developmental processes of bone formation: endochondral ossification and intramembranous ossification [295,296].…”

Section: Tissue Engineering and Regenerative Medicinementioning

confidence: 99%

Physical and mechanical properties of PLA, and their functions in widespread applications — A comprehensive review

Farah

Anderson

Langer

2016

Advanced Drug Delivery Reviews

2,376

1,486

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Available online xxxxPoly(lactic acid) (PLA), so far, is the most extensively researched and utilized biodegradable aliphatic polyester in human history. Due to its merits, PLA is a leading biomaterial for numerous applications in medicine as well as in industry replacing conventional petrochemical-based polymers. The main purpose of this review is to elaborate the mechanical and physical properties that affect its stability, processability, degradation, PLA-other polymers immiscibility, aging and recyclability, and therefore its potential suitability to fulfill specific application requirements. This review also summarizes variations in these properties during PLA processing (i.e. thermal degradation and recyclability), biodegradation, packaging and sterilization, and aging (i.e. weathering and hygrothermal). In addition, we discuss up-to-date strategies for PLA properties improvements including components and plasticizer blending, nucleation agent addition, and PLA modifications and nanoformulations. Incorporating better understanding of the role of these properties with available improvement strategies is the key for successful utilization of PLA and its copolymers/composites/blends to maximize their fit with worldwide application needs.© 2016 Elsevier B.V. All rights reserved. Contents lists available at ScienceDirectAdvanced Drug Delivery Reviews

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Section: Tissue Engineering and Regenerative Medicinementioning

confidence: 99%

Physical and mechanical properties of PLA, and their functions in widespread applications — A comprehensive review

Farah

Anderson

Langer

2016

Advanced Drug Delivery Reviews

2,376

1,486

View full text Add to dashboard Cite

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“…In vitro models can support almost all types of drug screening methods including free drugs, drug-delivery agents, implanted depots, liposomes, and nanoparticles. (16) At the early stage, most in vitro platforms are based on two-dimensional (2D) cell culturing platforms, (17,18) as shown in Fig. 1(a).…”

Section: Limitations Of Conventional Systemsmentioning

confidence: 99%

“…(19)(20)(21)(22) The most common 3D cell culturing platforms are cell aggregates, (21) spheroids, (19) and cell sheets. (18,22) Examples of cell aggregates and multicell-type sheets are shown in Figs. 1(b) and 1(c), respectively.…”

Section: Limitations Of Conventional Systemsmentioning

confidence: 99%

“…(87) (c) Multilayer 3D cell sheets with different types of cells. (18) (d) Light microscopy and scanning electron microscopy images of cell aggregates in microwells. (86) the interaction between the cellular microenvironments does not only include chemical responses but also mechanical and electrical interactions that can significantly affect cell behaviors.…”

Section: Limitations Of Conventional Systemsmentioning

confidence: 99%

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Organ-on-a-Chip Platforms for Drug Delivery and Cell Characterization: A Review

2015

Sensors and Materials

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“…ESP utilizes an electrostatic field to control the formation and deposition of polymer nanofibers [49][50][51]. The fibrous mesh also attributes in spatial arrangement (random or aligned), high porosity, mechanical property and increased surface area [52, 53] which can be controlled for production of efficient, reproducible, rapid and inexpensive sheets.…”

Section: Figure 2 Sem Image Of Free Form Fabricated Scaffold (Orientmentioning

confidence: 99%

Membrane supported scaffold architectures for tissue engineering

Bettahalli

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Prof. Dr. J. Vienken (Fresenius Medical Care, Germany) Dr. C. Legallais (Université de Technologie, France) Author -Narasimha Murthy Srivatsa BettahalliTitle -"Membrane supported scaffold architectures for tissue engineering"PhD Thesis, University of Twente, Enschede, The NetherlandsThe research described in this thesis was financially supported by STW (Utrecht, NL) (Project number -TKG.6716)Printed by: Gildeprint Drukkerijen, Enschede, The Netherlands Cover designed by NM Srivatsa BettahalliThe front cover shows dual flow glass bioreactor with 3D Free form fabricated scaffold integrated with hollow fibers (set-up artwork by Jonathan B Bennink of Tingle Visuals) and the back cover shows fluorescence microscope image of pre-labeled C2C12 cells cultured dynamically on multilayer cell-electrospun construct in dual flow perfusion bioreactor for 7 days (fluorescent image taken by Hemant Unadkat) and several SEM pictures at the top (PLLA hollow fiber, non-woven electrospun sheet and corrugated fiber) taken by the author. -3]. Along with the potential economic benefits from advanced tissue engineering technologies, reduced costs due to the availability of less expensive treatments for major medical problems is obvious, but indirect savings and dramatic improvements in treatment outcomes and quality of life for patients may prove to be even more important. There are several artificial tissues that are already being used for medical treatment (with limitations) which include fabricated skin, cartilage, blood vessels, bone, ligament and tendon [4][5][6]. It is also hoped that at least some of the whole organs like, liver, lung, kidney, pancreas, breast, intestine, etc. will become available off-the-shelf for treatment in the near future [7, 8]. MEMBRANE SUPPORTED SCAFFOLD ARCHITECTURES FOR TISSUE ENGINEERINGBesides the therapeutic application where the tissue is either grown in a patient (in-vivo) or outside the patient (in-vitro) and then transplanted to the patient, tissue engineering can have diagnostic applications where the tissue is made in-vitro and used for testing drug metabolism and uptake, toxicity, and pathogenicity [9][10][11][12]. The foundation of tissue engineering / regenerative medicine for either therapeutic or diagnostic applications is the ability to exploit living cells in a variety of ways.A tissue engineer first has to consider the function of the tissue -must it be strong? Elastic?Should it release certain proteins, like insulin from the pancreas, or filter toxins, like the kidneys? Then a 3D support must be designed that, when combined with cells, will eventually duplicate those functions, and continue to function properly in the body for years to come.Depending on the type of tissue, the design process can involve a variety of disciplines including mechanical / chemical engineering, molecular biology, physiology, medicine, polymer chemistry, and nanotechnology. Additionally, the scaffold can be constructed with or designed to release growth factors that can beneficially manipulate cell b...

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Development and analysis of multi-layer scaffolds for tissue engineering

Cited by 111 publications

References 21 publications

Physical and mechanical properties of PLA, and their functions in widespread applications — A comprehensive review

Physical and mechanical properties of PLA, and their functions in widespread applications — A comprehensive review

Organ-on-a-Chip Platforms for Drug Delivery and Cell Characterization: A Review

Membrane supported scaffold architectures for tissue engineering

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