Development and analytical performance of tubular polymer membrane electrode-based carbon dioxide catheters

Opdycke, Walter N.; Meyerhoff, Mark E.

doi:10.1021/ac00295a062

Cited by 23 publications

(15 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Originally, an ordinary glass electrode was used which is, however, not suitable for miniaturization. Therefore alternative pH measurement methods have been explored such as metal oxide electrodes (Tierney and Kim, 1993;Suzuki and Arakawa, 1999;Beyenal et al, 2004), solvent polymeric membrane electrodes (Opdycke and Meyerhoff, 1986;Shin et al, 2002;Zhao and Cai, 1997) and ion-selective field effect transistors (Arquint et al, 1993;Tsukada et al, 1990;Sekiguchi et al, 1998). Unfortunately, the above mentioned methods make use of an Ag/AgCl reference electrode which is known to suffer from drift and moreover needs regular maintenance because it is liquid filled.…”

Section: Introductionmentioning

confidence: 99%

A Miniaturized Carbon Dioxide Gas Sensor Based on Sensing of pH-Sensitive Hydrogel Swelling with a Pressure Sensor

Herber

Bomer

Olthuis

et al. 2005

Biomed Microdevices

View full text Add to dashboard Cite

A measurement concept has been realized for the detection of carbon dioxide, where the CO(2) induced pressure generation by an enclosed pH-sensitive hydrogel is measured with a micro pressure sensor. The application of the sensor is the quantification of the partial pressure of CO(2) (Pco(2)) in the stomach as diagnosis for gastrointestinal ischemia. The principle is put to the proof by examining the sensor response to changes in Pco(2). Furthermore, the response time, temperature-sensitivity and resolution are determined. The sensor responds well to changes in Pco(2) with a maximum pressure generation of 0.29 x 10(5) Pa at 20 kPa CO(2). The 90% response time varies between 1.5 and 4.5 minutes at 37( composite function)C. The sensor shows a linear temperature-sensitivity which can easily be compensated for, and enables detection of Pco(2) changes as small as 0.5 kPa CO(2).

show abstract

Section: Introductionmentioning

confidence: 99%

A Miniaturized Carbon Dioxide Gas Sensor Based on Sensing of pH-Sensitive Hydrogel Swelling with a Pressure Sensor

Herber

Bomer

Olthuis

et al. 2005

Biomed Microdevices

View full text Add to dashboard Cite

show abstract

“…In another approach, a neutral carrier-doped polymeric pH-sensitive electrode was employed as the internal sensing element in designing an implantable potentiometric pCO 2 sensor. 7 In this Severinghaustype configuration, a tubular pH electrode and a Ag/AgCl reference wire were housed inside a gas-permeable silicone rubber tube. This pCO 2 catheter design was further modified to devise a combined pCO 2 /K + -sensing probe by impregnating the outer silicone gas-permeable membrane with a potassium ionophore, valinomycin.…”

mentioning

confidence: 99%

Potentiometric pCO2 sensor using polyaniline-coated pH-sensitive electrodes

Cui¹,

Lee²,

Kim³

et al. 1998

Analyst

View full text Add to dashboard Cite

A very simple method of constructing a differential pCO 2 sensor device is described, using polyaniline-based pH electrodes in place of the pH-ISFET-based system employed previously. The polyaniline film-coated Pt electrode was shown to exhibit not only an enhanced potentiometric pH response but also a greatly reduced oxygen sensitivity compared with the uncoated Pt electrode. The proposed differential system employs two identical polyaniline electrodes to make a pCO 2 probe and a reference electrode. Both electrodes are made by coating the polyaniline surface with a gas-permeable silicone rubber membrane doped with valinomycin. The pCO 2 electrode is covered with a hydrogel-based recipient layer inside the gas-permeable membrane whereas the reference electrode does not have the hydrogel layer. In this sensor configuration, the emf differences between the pCO 2 and the reference electrodes serve as analytical signals and hence the ion responses caused by the two parts of the outer gas-permeable membranes cancel out. The polyaniline-based gas sensor system was shown to provide better emf stability than the uncoated Pt electrode-based counterpart.

show abstract

“…For example, O 2 , CO 2, and pH are involved in most of the fundamental mechanisms related to cellular metabolism and viability. Besides the glass pH electrode, polymeric pH electrodes have been utilized to fabricate P CO2 sensors for in vivo monitoring using similar mechanisms [116]. Currently, most of blood gas and electrolyte measurements are performed in discrete blood samples in laboratories which are remote from the patient.…”

Section: Importance Of Implantable Blood-gas Ph and Electrolyte Sensorsmentioning

confidence: 99%

Implantable Electrochemical Sensors for Biomedical and Clinical Applications: Progress, Problems, and Future Possibilities.

Dong²,

Cao³

et al. 2007

CMC

View full text Add to dashboard Cite

Biosensors are of great interest for their ability to monitor clinically important analytes such as blood gases, electrolytes, and metabolites. A classic example is to monitor the dynamics of blood-glucose levels for treating diabetes. However, the current practice, based on a three decade old technology, requires a drop of blood on a test strip, which is in dire need of replacement. The increasing demands and interests in developing implantable glucose sensors for treating diabetes has led to notable progress in this area, and various electrochemical sensors have been developed for intravascular and subcutaneous applications. However, implantations are plagued by biofouling, tissue destruction and infection around the implanted sensors and the response signals must be interpreted in terms of blood or plasma concentrations for clinical utility, rather than tissue fluid levels. This review focuses on the potentials and pitfalls of implantable electrochemical sensors and presents our opinions about future possibilities of such implantable devices with respect to biocompatibility issues, long-term calibration, and other aging effects on the sensors.

show abstract

Development and analytical performance of tubular polymer membrane electrode-based carbon dioxide catheters

Cited by 23 publications

References 27 publications

A Miniaturized Carbon Dioxide Gas Sensor Based on Sensing of pH-Sensitive Hydrogel Swelling with a Pressure Sensor

A Miniaturized Carbon Dioxide Gas Sensor Based on Sensing of pH-Sensitive Hydrogel Swelling with a Pressure Sensor

Potentiometric pCO2 sensor using polyaniline-coated pH-sensitive electrodes

Implantable Electrochemical Sensors for Biomedical and Clinical Applications: Progress, Problems, and Future Possibilities.

Contact Info

Product

Resources

About