Development and Application of 3D Bioprinted Scaffolds Supporting Induced Pluripotent Stem Cells

Lu, Dezhi; Liu, Yang; Li, Wentao; Ma, Haitao; Li, Tao; Ma, Xiao‐Jun; Mao, Yuanqing; Liang, Qianqian; Ma, Zhen; Wang, Jinwu

doi:10.1155/2021/4910816

Cited by 6 publications

(1 citation statement)

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“…The conventional biological scaffolds are prepared by methods of gas flocculation, particle rinsing, and phase isolation. 39–41 …”

Section: Introduction Of 3d Printing Technology Different 3d Printing...mentioning

confidence: 99%

The Dual Effect of 3D-Printed Biological Scaffolds Composed of Diverse Biomaterials in the Treatment of Bone Tumors

Ma¹,

Zhang²,

Sun³

et al. 2023

IJN

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Bone tumors, including primary bone tumors, invasive bone tumors, metastatic bone tumors, and others, are one of the most clinical difficulties in orthopedics. Once these tumors have grown and developed in the bone system, they will interact with osteocytes and other environmental cells in the bone system’s microenvironment, leading to the eventual damage of the bone’s physical structure. Surgical procedures for bone tumors may result in permanent defects. The dual-efficacy of tissue regeneration and tumor treatment has made biomaterial scaffolds frequently used in treating bone tumors. 3D printing technology, also known as additive manufacturing or rapid printing prototype, is the transformation of 3D computer models into physical models through deposition, curing, and material fusion of successive layers. Adjustable shape, porosity/pore size, and other mechanical properties are an advantage of 3D-printed objects, unlike natural and synthetic material with fixed qualities. Researchers have demonstrated the significant role of diverse 3D-printed biological scaffolds in the treatment for bone tumors and the regeneration of bone tissue, and that they enhanced various performance of the products. Based on the characteristics of bone tumors, this review synthesized the findings of current researchers on the application of various 3D-printed biological scaffolds including bioceramic scaffold, metal alloy scaffold and nano-scaffold, in bone tumors and discussed the advantages, disadvantages, and future application prospects of various types of 3D-printed biological scaffolds. Finally, the future development trend of 3D-printed biological scaffolds in bone tumor is summarized, providing a theoretical foundation and a larger outlook for the use of biological scaffolds in the treatment of patients with bone tumors.

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“…The conventional biological scaffolds are prepared by methods of gas flocculation, particle rinsing, and phase isolation. 39–41 …”

Section: Introduction Of 3d Printing Technology Different 3d Printing...mentioning

confidence: 99%

The Dual Effect of 3D-Printed Biological Scaffolds Composed of Diverse Biomaterials in the Treatment of Bone Tumors

Ma¹,

Zhang²,

Sun³

et al. 2023

IJN

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Recent Advances in Gelatin Methacryloyl Hydrogels for Bone Regeneration

Guo,

Meng,

Wang

et al. 2024

ACS Appl. Nano Mater.

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The repair of bone defects has been the focus of research at home and abroad in recent years. Gelatin methacryloyl (GelMA) hydrogels, with their good biocompatibility, low cost, photo-cross-linking structure, and easily adjustable physicochemical property, have been widely used in bone regeneration. GelMA hydrogels can overcome issues such as inadequate mechanical property, poor bioactivity, and uncontrolled degradation through various strategies. This paper presents a systematic review of recent advances in GelMA hydrogels in the field of bone defect repair, covering the preparation of GelMA hydrogels and the effect of reaction conditions on the property, the loading and controlled release of GelMA hydrogels (drugs, cells, growth factors, exosomes), material hybridization (organic nanomaterials, inorganic nanomaterials, organic and inorganic hybrid materials) of GelMA hydrogels, structural modulation (electrostatic spinning, microspheres, 3D printing), as well as the mechanism of osteogenic activity (vascular, neural, immunomodulation) in bone defects. Finally, we summarized this article and looked forward to the prospects and challenges of GelMA hydrogel in repairing bone defects.

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