Development and Application of Organic Reagents for Analysis. VI. Synthesis and Fluorescence Spectral Properties of 2-(4-Substituted phenyl)benzofurans

Akiyama, Shuzo; Akimoto, Hiroyuki; Nakatsuji, Shin’ichi; Nakashima, Kenichiro

doi:10.1246/bcsj.58.2192

Cited by 26 publications

(5 citation statements)

References 4 publications

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“…Analytical Data for the Suzuki-Miyaura Coupling Products 2-(4'-Methoxyphenyl)pyridine: [19] Colorless solid; 2-(4'-Chlorophenyl)pyridine: [19] Colorless oil; 2-(4'-Nitrophenyl)benzofuran: [22] Yellow solid; 2-(4'-Nitrophenyl)benzothiophene: [23] [25] Colorless oil; …”

Section: Experimental Section General Methodsmentioning

confidence: 99%

Ligand‐Free and Heterogeneous Palladium on Carbon‐Catalyzed Hetero‐Suzuki–Miyaura Cross‐Coupling

et al. 2010

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A ligand-free and heterogeneous palladium on carbon (Pd/C)-catalyzed hetero-SuzukiMiyaura coupling reaction has been developed. The protocol enables the construction of both heterocyclic-alicyclic and heterocyclic-heterocyclic biaryl derivatives in good to excellent yields. Furthermore, Pd/C could be reused. The time-course study clarified that palladium was leached into the reaction media as the reaction proceeded and then completely deposited on the carbon support.

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Section: Experimental Section General Methodsmentioning

confidence: 99%

Ligand‐Free and Heterogeneous Palladium on Carbon‐Catalyzed Hetero‐Suzuki–Miyaura Cross‐Coupling

et al. 2010

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“…2‐(4′‐Nitrophenyl)benzofuran: 22 Yellow solid; 1 H NMR: δ =8.30 (d, J =8.8 Hz, 2 H), 7.99 (d, J =8.8 Hz, 2 H), 7.64 (d, J =8.0 Hz, 1 H), 7.55 (d, J =8.0 Hz, 1 H), 7.37 (t, J =8.0 Hz, 1 H), 7.30–7.23 (m, 2 H); 13 C NMR: δ =155.4, 153.2, 147.3, 136.3, 128.6, 125.8, 125.2, 124.3, 123.5, 121.6, 111.5, 105.1; MS (EI): m/z =239 (M + , 100%); HR‐MS (EI): m/z = 239.0588, calcd for C 14 H 9 NO 3 (M + ) 239.0583.…”

Section: Methodsmentioning

confidence: 99%

P253: Middle cerebral artery Doppler assessment of fetal anemia in the surviving co-twin after laser therapy for twin-twin transfusion syndrome

Nakata¹,

Ishii²,

Chmait

et al. 2003

Ultrasound Obstet Gynecol

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th World Congress on Ultrasound in Obstetrics and GynecologyPoster abstracts (P = 0.11). The mean duration of sampling was 144 ± 188 sec with a 22 G needle versus 144 ± 120 sec with a 23 G needle (P = 0.99). No significant differences were noted in sampling time between the two needle types. Four of the six operators showed a clear learning curve with shorter sampling times with increasing number of procedures.Conclusion: This experimental study shows that the use of a 23 G echo-tip  needle compared to a 22 G needle was not associated with significantly different procedure duration or defect size, therefore not supporting the claimed advantages of this more expensive needle. Objective: To evaluate whether ultrasound screening during pregnancy increases the ability to stop or reduce smoking. Methods: This multicenter questionnaire study was performed to describe smoking characteristics among pregnant women and evaluate the factors that influence the ability to reduce smoking during pregnancy. The ultrasound screening was examine as one factor. Women were interviewed within 2 days after deliverance in the maternity units on smoking habits before and during pregnancy. Each maternity was visited only once. The study was conducted during May and June 2002 in multiple practices in 4 French regions: Nord-Pas de Calais, Languedoc-Roussillon, HauteNormandie and Ile de France. Only two investigators interviewed consenting patients, both were tabacologists. Results: 979 women delivered were asked to participate. Three hundred three women (31%) were smoking regularly before pregnancy. Nearly all (98%) of them tried to change their smoking habits. More than one third (38.0%) of women reported that ultrasound was a positive tool to enhance motivation to reduce smoking. Ultrasound screening may be a positive factor to reduce smoking. However most women who stop smoking during pregnancy do so in the first trimester (84%) mainly before the first ultrasound exam. Thus, the routine ultrasound scan itself does not seem to influence attitudes to stop smoking any further. Conclusion: Ultrasound screening during pregnancy is a tool which may be included in comprehensive and individualized anti smoking support. P252 P252aOutcome of amniocentesis performed in a Perinatology Unit over 5 years L. Onderoglu, O. Deren, B. Saygan-Karamursel, A. B. Savas-Alparslan, A. Kizilkilic-Parlakgumus, T. Durukan and E. Tuncbilek Hacettepe University Hospital, TurkeyObjective: To investigate the indications, results and fetal loss rates of amniocentesis performed at a Perinatology Unit during 1998-2002. Methods: Amniocentesis records from January 1998 to July 2002 were retrospectively reviewed from a computer based system at the Perinatology Unit. Patient records at the Genetic Unit were reviewed for karyotype results. All of the patients who did not deliver at our hospital were called by telephone to learn about the pregnancy outcome. Results: A total of 1837 amniocentesis procedures were performed. The most common indication was advanced maternal age...

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“…A group of researchers reported several kinds of intramolecular cyclization of 2-alkoxyacetophenones (10a) have been described, resulting in 2-R-3-methylbenzofurans (10b). As condensing agents, Na and K alcoholates [61][62][63] or alkalis [64][65][66][67][68] in the polar solvent/environment are being utilized [69,70] as shown in fig. 2j.…”

Section: Cholinesterase Inhibitormentioning

confidence: 99%

Recent Advancement of Benzofuran in Treatment of Alzheimer’s Disease

Sahu,

Shah,

Misbah

et al. 2023

IJPS

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Benzofuran in Treatment of Alzheimer's DiseaseAlzheimer's disease is a neurodegenerative disease that impairs motor and cognitive function it is spreading very quickly in the current scenario with a male:female ratio between 1:2 to 1:5 due to various causes associated with it which include education, diet and nutrition, sleep and cardiac rhythm and head trauma etc. Previously available drugs like tacrine failed to prove their efficacy and later were withdrawn from the market due to excess toxicity, lower solubility, and slow bioavailability. Among them, benzofuran-based drugs make a significant contribution because they are one of the important pharmacophores found both synthetically and naturally in heterocyclic compounds, with a wide range of therapeutic applications in the field of drug discovery that offers many opportunities for further improvement in anti-Alzheimer agents by acting on numerous prominent receptors. So, this article focuses on various benzofuran derivatives and their advancement in the treatment of Alzheimer's disease with a summary of the synthesis of benzofuran and benzofuran-based derivatives which assist scientists in developing successful medications with the necessary pharmacological action.

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Development and Application of Organic Reagents for Analysis. VI. Synthesis and Fluorescence Spectral Properties of 2-(4-Substituted phenyl)benzofurans

Abstract: A synthesis of fifteen kinds of 2-(4-substituted phenyl)benzofurans (4n) was carried out and their fluorescence spectral properties were investigated concerning their applicability as organic reagents for analyses.

Cited by 26 publications

References 4 publications

Ligand‐Free and Heterogeneous Palladium on Carbon‐Catalyzed Hetero‐Suzuki–Miyaura Cross‐Coupling

Ligand‐Free and Heterogeneous Palladium on Carbon‐Catalyzed Hetero‐Suzuki–Miyaura Cross‐Coupling

P253: Middle cerebral artery Doppler assessment of fetal anemia in the surviving co-twin after laser therapy for twin-twin transfusion syndrome

Recent Advancement of Benzofuran in Treatment of Alzheimer’s Disease

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