Development and bioavailability assessment of ramipril nanoemulsion formulation

Sheikh, Saifuddin; Shakeel, Faiyaz; Talegaonkar, Sushama; Ahmad, Feroz; Khar, Roop K.; Ali, Mushir

doi:10.1016/j.ejpb.2006.10.014

Cited by 621 publications

(370 citation statements)

References 41 publications

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“…In vitro drug release showed that drug release till 24 h from nanoemulsion and was highly significant (p<0.01) as compared to marketed capsule formulation and drug suspension. The relative bioavailability of ramipril nanoemulsion to that of conventional capsule was 229.62% and to drug suspension was 539.49 suggesting the use of developed ramipril nanoemulsion for pediatric and geriatric patients [52]. In another study, they investigated effect of Labrasol on self-nanoemulsification efficiency of ramipril nanoemulsion [53].…”

Section: Drug Delivery Explored In Tb Chemotherapy Liposomesmentioning

confidence: 99%

Present status of nanoparticle research for treatment of Tuberculosis

2011

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-Nanotechnology has offered enormous improvement in field of therapeutics by means of designing of drug delivery systems and opened the possibility of controlling infections at the molecular level. Nanocarriers can cross biological barriers and are able to target cellular reservoirs of Mycobacterium tuberculosis (M. tuberculosis). Nanoparticle-based systems have significant potential for treatment and prevention of tuberculosis (TB). A variety of nanocarriers have been widely evaluated as potential drug delivery systems for various administration routes. Targeting the drugs to certain physiological sites such as the lymph nodes has emerged as a promising strategy in treating TB with improved drug bioavailability and reduction of the dosing frequency. Nanotechnology based rational targeting may improve therapeutic success by limiting adverse drug effects and requiring less frequent administration regimes, ultimately resulting in more patients compliance and thus attain higher adherence levels. The development of nanoparticle based aerosol vaccine is undergoing which could serve as new platform for immunization. Present article compiles the general physiological aspects of the infection along with new research uptades on nanocarriers used in prevention of tuberculosis. _______________________________________________________________________________________

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Section: Drug Delivery Explored In Tb Chemotherapy Liposomesmentioning

confidence: 99%

Present status of nanoparticle research for treatment of Tuberculosis

2011

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“…Thermodynamic stability of MEs was assessed by the three-step procedure as reported by Shafiq et al with slight modification (30).…”

Section: Thermodynamic Stability Studiesmentioning

confidence: 99%

Development of Novel Ionic Liquid-Based Microemulsion Formulation for Dermal Delivery of 5-Fluorouracil

et al. 2014

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Abstract. The present study was aimed at synthesizing an imidazole-based ionic liquid 1-butyl-3-methylimidazolium bromide (BMIMBr) and subsequent development of a novel ionic liquid-in-oil (IL/o) microemulsion (ME) system for dermal delivery of a poorly permeating drug 5-fluorouracil (5-FU). A significant enhancement in the solubility of 5-FU was observed in BMIMBr. IL/o MEs of 5-FU were prepared using isopropyl myristate, Tween 80/Span 20, and BMIMBr. Results of ex vivo skin permeation studies through mice skin indicated that the selected IL/o ME exhibited 4-fold enhancement in percent drug permeation as compared to aqueous solution, 2.3-fold as compared to hydrophilic ointment, and 1.6-fold greater permeation than water in oil (w/o) ME. The results of in vivo studies against dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mice skin carcinogenesis demonstrated that the IL/o ME could effectively treat skin cancer in 4 weeks. In addition, the side effects such as erythema and irritation associated with the conventional formulations were not observed. Histopathological studies showed that the use of IL/o ME caused no anatomic and pathological changes in the skin structure of mice. These studies suggest that the use of IL-based ME system can efficiently enhance the solubility and permeability of 5-FU and hence its therapeutic efficacy.KEY WORDS: 5-fluorouracil; dermal delivery; ionic liquids; ionic liquid in oil (IL/o) microemulsion; skin cancer.

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“…In order to evaluate the emulsification efficiency of NE formulations upon infinite dilution in GI fluid, double-distilled water was used as a dispersion medium. This selection was based on the report corroborating insignificant difference in the behavior of NE, prepared using nonionic surfactants, dispersed in either water or simulated gastric or intestinal fluid (21,22). The formulations that passed the dispersibility test in double-distilled water in grade(s) A and B were selected for further study as these formulations were certain to remain as NE upon dispersion in the aqueous environment of the GI tract (Table I).…”

Section: Dispersibiltymentioning

confidence: 99%

Product Development Studies on Surface-Adsorbed Nanoemulsion of Olmesartan Medoxomil as a Capsular Dosage Form

2012

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Abstract. The present study aimed at development of capsular dosage form of surface-adsorbed nanoemulsion (NE) of olmesartan medoxomil (OLM) so as to overcome the limitations associated with handling of liquid NEs without affecting their pharmaceutical efficacy. Selection of oil, surfactant, and cosurfactant for construction of pseudoternary phase diagrams was made on the basis of solubility of drug in these excipients. Rationally selected NE formulations were evaluated for percentage transmittance, viscosity, refractive index, globule size, zeta potential, and polydispersity index (PDI). Formulation (F3) comprising of Capmul MCM® (10% v/v), Tween 80® (11.25% v/v), polyethylene glycol 400 (3.75% v/v), and double-distilled water (75% v/v) displayed highest percentage cumulative drug release (%CDR; 96.69± 1.841), least globule size (17.51±5.87 nm), low PDI (0.203±0.032), high zeta potential (−58.93±0.98 mV), and hence was selected as the optimized formulation. F3 was adsorbed over colloidal silicon dioxide (2 ml/400 mg) to produce free-flowing solid surface-adsorbed NE that presented a ready-to-fill capsule composition. Conversion of NE to surface-adsorbed NE and its reconstitution to NE did not affect the in vitro release profile of OLM as the similarity factor with respect to NE was found to be 66% and 73% respectively. The %CDR after 12 h for optimized NE, surface-adsorbed NE, and reconstituted NE was found to be 96.69±0.54, 96.07±1.76, and 94.78±1.57, respectively (p>0.05). The present study established capsulated surfaceadsorbed NE as a viable delivery system with the potential to overcome the handling limitations of NE.

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Development and bioavailability assessment of ramipril nanoemulsion formulation

Cited by 621 publications

References 41 publications

Present status of nanoparticle research for treatment of Tuberculosis

Present status of nanoparticle research for treatment of Tuberculosis

Development of Novel Ionic Liquid-Based Microemulsion Formulation for Dermal Delivery of 5-Fluorouracil

Product Development Studies on Surface-Adsorbed Nanoemulsion of Olmesartan Medoxomil as a Capsular Dosage Form

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