Development and biological evaluation of protective effect of kidney targeted N-acetylated chitosan nanoparticles containing thymoquinone for the treatment of DNA damage in cyclophosphamide-induced haemorrhagic cystitis

Prajapati, Chaitali P.; Agrawal, Yogeeta O.; Agnihotri, Vinit V.; Mahajan, Umesh B; Patil, Kiran; Patil, Dipak D.; Patil, Chandragouda R.

doi:10.1016/j.ijbiomac.2022.06.070

Cited by 8 publications

(3 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Earlier reports have validated the capability of TQNP to defend the renal tissues against damage in a rat model cancer (Harakeh et al, 2022), hemorrhagic cystitis (Prajapati et al, 2022) and nephrotoxicity. The existing data encourage the nephroprotective ability of TQNP and introduce more evidence of its capability in attenuating PAR nephrotoxicity.…”

Section: Discussionmentioning

confidence: 87%

Effects of Thymoquinone Nanoparticles on Paracetamol-Induced Nephrotoxicity by Mitigating Oxidative Stress and Inflammation in Rats

Alaryani

2024

Annals of Animal Science

View full text Add to dashboard Cite

A common and efficient analgesic-antipyretic medication for a variety of syndromes is paracetamol (PAR). The use of PAR was associated with acute kidney injury and other side effects, and its hazardous effects were influenced by oxidative stress and inflammation. Black seed oil's primary active ingredient, thymoquinone (TQ), has anti-inflammatory, immunomodulatory, and antioxidant properties. A few animal models for drug-induced nephrotoxicity described promising outcomes of its renoprotective action. The main goal of this work was to evaluate TQ nanoparticles' (TQNP) powerful renoprotective properties in a rat model of nephrotoxicity caused by PAR. Three groups of eight rats each were assigned; group one (the control group, CON) was given gavaged normal saline. Group 2 (PAR group, PAR) received 600 mg/kg of gavaged PAR diluted in regular saline. One hour after PAR delivery, group 3 (the TQNP group) received TQNP 0.5 mg/kg via oral administration. In rat kidney tissues, PAR resulted in renal damage, a rise in blood urea nitrogen (BUN), creatinine, cystatin C (CYC), myeloperoxidase, protein carbonyl (PC), malondialdehyde (MDA), and a decrease in nitric oxide and cellular antioxidants. In rats given PAR, TQNP effectively reduced renal damage, lowered serum levels of creatinine, BUN, and CYC, and improved oxidative stress (MDA, MYO, and PC) and inflammatory markers (TNFα and IFN-γ). TQNP treatment resulted in modestly dilated/congested blood vessels in the renal tissues of PAR. The TQNP's reno-protective action is an effective preventative against PAR-induced nephrotoxicity, primarily by enhancing cellular defense mechanisms and reducing inflammatory and oxidative indicators in a rat model. However, additional research and clinical trials should be needed for testing in future studies.

show abstract

Section: Discussionmentioning

confidence: 87%

Effects of Thymoquinone Nanoparticles on Paracetamol-Induced Nephrotoxicity by Mitigating Oxidative Stress and Inflammation in Rats

Alaryani

2024

Annals of Animal Science

View full text Add to dashboard Cite

show abstract

“…The study showed that the thymoquinone-N-alkylated chitosan nanoparticles were effectively delivered to the kidney and improved its protective efficacy against cyclophosphamide-induced hemorrhagic cystitis. 19 N-acylated chitosan was used for the stabilization of glabridin, a polyphenolic compound isolated from licorice root by forming a chitosan nano-complex. It has been shown that chitosan derivatives can be used as a stabilizer for polyphenolic compounds and potentially applied to skin-whitening agents.…”

Section: Solubility Improvement Of Chitosanmentioning

confidence: 99%

The Chemical Modification to Improve Solubility of Chitosan and Its Derivatives Application, Preparation Method, Toxicity as a Nanoparticles

Suryani,

Chaerunisaa,

Joni

et al. 2024

NSA

View full text Add to dashboard Cite

Chitosan is a functional polymer in the pharmaceutical field, including for nanoparticle drug delivery systems. Chitosan-based nanoparticles are a promising carrier for a wide range of therapeutic agents and can be administered in various routes. Solubility is the main problem for its production and utilization in large-scale industries. Chitosan modifications have been employed to enhance its solubility, including chemical modification. Many reviews have reported the chemical modification but have not focused on the specific characteristics obtained. This review focused on the modification to improve chitosan solubility. Additionally, this review also focused on the application of chitosan derivatives in nanoparticle drug delivery systems since very few similar reviews have been reported. The specific method for chitosan derivative-based nanoparticles was also reported and the latest report of chitosan, chitosan derivative, and chitosan toxicity were also described.

show abstract

“…As stated in the previous section, chitosan nanoparticles are excellent carriers for drug delivery to the kidney. C. Prajapati et al [ 91 ] synthesized N-acetylated chitosan nanoparticles capable of renal targeting for the encapsulation of thymoquinone (TQ) to treat hemorrhagic cystitis. They successfully prepared a TQ-nanoparticles formulation using an ionic gelation technique with N-acetylated chitosan, tripolyphosphate, TQ, and methanol.…”

Section: Biopolymers and Their Application In Renal Diseasesmentioning

confidence: 99%

Biopolymer-Based Nanosystems: Potential Novel Carriers for Kidney Drug Delivery

Li,

Dai,

Xiao

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Kidney disease has become a serious public health problem throughout the world, and its treatment and management constitute a huge global economic burden. Currently, the main clinical treatments are not sufficient to cure kidney diseases. During its development, nanotechnology has shown unprecedented potential for application to kidney diseases. However, nanotechnology has disadvantages such as high cost and poor bioavailability. In contrast, biopolymers are not only widely available but also highly bioavailable. Therefore, biopolymer-based nanosystems offer new promising solutions for the treatment of kidney diseases. This paper reviews the biopolymer-based nanosystems that have been used for renal diseases and describes strategies for the specific, targeted delivery of drugs to the kidney as well as the physicochemical properties of the nanoparticles that affect the targeting success.

show abstract

Development and biological evaluation of protective effect of kidney targeted N-acetylated chitosan nanoparticles containing thymoquinone for the treatment of DNA damage in cyclophosphamide-induced haemorrhagic cystitis

Cited by 8 publications

References 38 publications

Effects of Thymoquinone Nanoparticles on Paracetamol-Induced Nephrotoxicity by Mitigating Oxidative Stress and Inflammation in Rats

Effects of Thymoquinone Nanoparticles on Paracetamol-Induced Nephrotoxicity by Mitigating Oxidative Stress and Inflammation in Rats

The Chemical Modification to Improve Solubility of Chitosan and Its Derivatives Application, Preparation Method, Toxicity as a Nanoparticles

Biopolymer-Based Nanosystems: Potential Novel Carriers for Kidney Drug Delivery

Contact Info

Product

Resources

About