Development and cell fate in interspecific (mus musculus/mus caroli) intraocular transplants of mouse molar tooth-germ tissues detected by in situ hybridization

Lubbock, M.J.; Harrison, V.T.; Lumsden, Andrew; Palmer, Richard Phillips

doi:10.1016/0003-9969(95)00094-1

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…The gingival tissues appear to be derived from both the oral mucosa and the developing tooth germ (135). It has been suggested that the dental follicle (connective tissue surrounding the developing teeth) gives rise to the fibroblasts forming the periodontal ligament as well as to the alveolar bone and cementoblasts (45, 136, 186, 243), all of which have a common neural crest origin (34). Therefore, it is postulated that there are different types of cementoblasts: those originating from the Hertwig's epithelial root sheath via epithelial–mesenchymal transformation and which form the acellular cementum; and those derived from the dental follicle, which form the cellular cementum (9, 19, 105, 251, 275).…”

Section: Development Of the Periodontiummentioning

confidence: 99%

Regeneration of periodontal tissues: cementogenesis revisited

Zeichner‐David¹

2006

Periodontology 2000

117

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Section: Development Of the Periodontiummentioning

confidence: 99%

Regeneration of periodontal tissues: cementogenesis revisited

Zeichner‐David¹

2006

Periodontology 2000

117

View full text Add to dashboard Cite

Development and cell fate in interspecific (Mus musculus/Mus caroli) orthotopic transplants of mouse molar tooth germs detected by in situ hybridization11Based on a thesis submitted to London University in partial fulfillment of the requirements for the PhD degree

Carlile¹,

Harrison²,

Lumsden³

et al. 1998

Archives of Oral Biology

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The induction of enamel and dentin complexes by subcutaneous implantation of reconstructed human and murine tooth germ elements

Isogawa

Terashima

Nakano

et al. 2004

Archives of Histology and Cytology

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Tooth induction by xenogenic graft of reconstructed human tooth germ components has never been attempted. Here we report our first attempt at a transplantation of human tooth germ components, heterologously recombined with mouse dental epithelia, into immunocompromised animals. Human third molar tooth germs enucleated from young patients as prophylactic treatment for orthodontic reasons were collected. The whole or minced human dental papilla was reconstructed with human- or mouse molar enamel epithelium, and transplanted in the dorsal aspect of C.B-17/Icr-scid Jcl mice. The transplant of human dental papilla reconstructed with human enamel epithelium formed thin dentin and immature enamel layers by 3 to 4 weeks, but remained extremely small in quantity due to a shortage of epithelial components in the graft. The addition of E16 mouse molar enamel organs (n=10-12) to each graft augmented the formation of tooth germ-like structures, but the differentiation of mouse molar ameloblasts was suppressed. However, once a solid layer of mineralized dentin was established, mouse ameloblasts accelerated their differentiation, and completed the enamel matrix formation and maturation within the following 4 weeks, whereas human ameloblasts, which had interacted with human dental papilla, remained in the stage of matrix formation during the same period. These data imply that, in reconstructed transplants, the differentiation of mouse dental epithelia is restrained by putative suppressive factors derived from human dental papilla until they are separated by mineralized dentin layers that serve as a diffusion barrier. The mouse enamel organ nevertheless retains its own phenotypic characteristics and intrinsic timing of cell differentiation and function.

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Development and cell fate in interspecific (mus musculus/mus caroli) intraocular transplants of mouse molar tooth-germ tissues detected by in situ hybridization

Cited by 3 publications

References 27 publications

Regeneration of periodontal tissues: cementogenesis revisited

Regeneration of periodontal tissues: cementogenesis revisited

Development and cell fate in interspecific (Mus musculus/Mus caroli) orthotopic transplants of mouse molar tooth germs detected by in situ hybridization11Based on a thesis submitted to London University in partial fulfillment of the requirements for the PhD degree

The induction of enamel and dentin complexes by subcutaneous implantation of reconstructed human and murine tooth germ elements

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