Development and characterization of a dry reservoir-hydrogel-forming microneedles composite for minimally invasive delivery of cefazolin

Sabri, Akmal Hidayat Bin; Anjani, Qonita Kurnia; Utomo, Emilia; Ripolin, Anastasia; Donnelly, Ryan F.

doi:10.1016/j.ijpharm.2022.121593

Cited by 34 publications

(21 citation statements)

References 48 publications

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“…Sabri et al delivered cefazolin (CFZ), a bacteriolysis-induced β-lactam antibiotic, in a minimally invasive manner through a polymeric reservoir combined with sharp pyramidal hydrogel microneedles that were 600 μm high and composed of poly(methyl vinyl ether-co-maleic acid) cross-linked by esterification with PEG-10000 (Figure 1a, b). 75 Optical coherence tomography revealed that the microneedles became inserted into dermal skin layers by applying manual pressure for only 30 s (Figure 1c). The amounts of CFZ in the microneedles, epidermis, and dermis at various times were measured following extraction (Figure 1d−f).…”

Section: Hydrogel-based Strategy For Osteomyelitis Treatmentmentioning

confidence: 99%

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Hydrogel-Based Strategies for the Management of Osteomyelitis

Kuo

Lin

Yeh

2023

ACS Biomater. Sci. Eng.

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Osteomyelitis is a type of bone infection caused by bacteria, with Staphylococcus sepsis being responsible for most cases. Osteomyelitis treatment generally requires a multifaceted approach that may include intervention of surgery and administration of antibacterial agents, where several materials have been utilized as delivery vehicles for antibiotics and other antibacterial materials. Hydrogel has become a popular candidate for osteomyelitis treatment due to its biocompatibility, water-containing porous structure, and adaptable physicochemical properties. In this review, we discuss several hydrogel-based strategies for osteomyelitis treatment and categorized them based on the encapsulated cargos (i.e., antibiotics, silver nanoparticles, protein and bacteriophage, and reactive oxygen species (ROS) generator). Several representative examples of osteomyelitis treatment using hydrogels are described here, focusing on their design, preparation, properties, and outcomes. We also provide our perspectives on the remaining concerns regarding fabricating advanced hydrogels for osteomyelitis treatment. This review will be valuable to the hydrogel community and inspire researchers to develop next-generation hydrogels for specific and practical clinical applications in osteomyelitis.

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Section: Hydrogel-based Strategy For Osteomyelitis Treatmentmentioning

confidence: 99%

Section: Hydrogel-based Strategy For Osteomyelitis Treatmentmentioning

confidence: 99%

Hydrogel-Based Strategies for the Management of Osteomyelitis

Kuo

Lin

Yeh

2023

ACS Biomater. Sci. Eng.

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“…They created two distinct CFZ-loaded dry reservoirs, which were then evaluated based on directly compressed tablets (DCT) and lyophilized (LYO) wafers. They concluded that the dry reservoir systems showed fast dissolution, dissolving in phosphate buffer saline pH 7.4 in less than one minute 99 .…”

Section: Insertsmentioning

confidence: 99%

Untitled

2023

IJPSR

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For almost five decades, from its application in preserving blood plasma to stabilizing pharmaceuticals and biopharmaceuticals, lyophilization has been used in life sciences. Lyophilization is a popular drying technique for preserving various drugs, formulations and biological materials such as proteins, plasma, and living cells. The researchers have made significant efforts to develop lyophilized nanoparticulate drug delivery formulations. During lyophilization, biological products and vaccines could be increased by removing solvents and the shelf-life of injectables. Thus, lyophilization unstable or heatsensitive drugs/biologicals can be dried at low temperatures without damaging their physical structure. Lyophilized products can be reconstituted quickly and easily, improving shelf life and easy transportation. Vast applications of lyophilization in the Pharmaceutical Area established the importance of lyophilization techniques in the pharmaceutical field. The present review aims to update recent and advanced applications of Lyophilization techniques in Pharmaceuticals and biological products such as Antibiotics, Vaccines, proteins, enzymes, and hormones.

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“…In the work, the researchers fabricated a hydrogel forming microneedle system from Gantrez® S-97 and Carbopol® 974P NF crosslinked with PEG 10,000 that was used in combination with an antibiotic loaded lyophalised wafer. The composite microneedle-based pharmaceutical system was capable of delivering 500 µg of cefazolin into the dermis within 2 h of application furthering highlighting the utility of microneedle as a delivery system for localised intradermal delivery of antimicrobial agents ( 19 ). Nevertheless, there is no publication to date that have demonstrated the capability of using microneedles as a potential physical permeation enhancer to promote the delivery of antiseptic agent such as CHG into the skin as a prophylaxis treatment against potential skin infection following surgical incision as most microneedle system developed has been focussed on the treatment of established skin infections.…”

Section: Introductionmentioning

confidence: 98%

Microneedle-Mediated Permeation Enhancement of Chlorhexidine Digluconate: Mechanistic Insights Through Imaging Mass Spectrometry

et al. 2022

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Purpose Chlorhexidine digluconate (CHG) is a first-line antiseptic agent typically applied to the skin as a topical solution prior to surgery due to its efficacy and safety profile. However, the physiochemical properties of CHG limits its cutaneous permeation, preventing it from reaching potentially pathogenic bacteria residing within deeper skin layers. Thus, the utility of a solid oscillating microneedle system, Dermapen®, and a CHG-hydroxyethylcellulose (HEC) gel were investigated to improve the intradermal delivery of CHG. Methods Permeation of CHG from the commercial product, Hibiscrub®, and HEC-CHG gels (containing 1% or 4% CHG w/w) was assessed in intact skin, or skin that had been pre-treated with microneedles of different array numbers, using an Franz diffusion cells and Time-of-Flight Secondary Ion Mass Spectrometry (ToF–SIMS). Results Gels containing 1% and 4% CHG resulted in significantly increased depth permeation of CHG compared to Hibiscrub® (4% w/v CHG) when applied to microneedle pre-treated skin, with the effect being more significant with the higher array number. ToF–SIMS analysis indicated that the depth of dermal penetration achieved was sufficient to reach the skin strata that typically harbours pathogenic bacteria, which is currently inaccessible by Hibiscrub®, and showed potential lateral diffusion within the viable epidermis. Conclusions This study indicates that HEC-CHG gels applied to microneedle pre-treated skin may be a viable strategy to improve the permeation CHG into the skin. Such enhanced intradermal delivery may be of significant clinical utility for improved skin antisepsis in those at risk of a skin or soft tissue infection following surgical intervention.

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Development and characterization of a dry reservoir-hydrogel-forming microneedles composite for minimally invasive delivery of cefazolin

Cited by 34 publications

References 48 publications

Hydrogel-Based Strategies for the Management of Osteomyelitis

Hydrogel-Based Strategies for the Management of Osteomyelitis

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Microneedle-Mediated Permeation Enhancement of Chlorhexidine Digluconate: Mechanistic Insights Through Imaging Mass Spectrometry

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