“…In its simplest form, LIAD has a layout where the molecules of interest (analytes) are deposited on the front side of a thin metal foil facing the mass spectrometer, while the laser irradiates the back side of the film launching an acoustic pulse toward the front surface and leading to the desorption of the analytes. ,− Placing the irradiated side of the metal foil in direct contact with an optically transparent solid substrate of liquid layer has been shown to increase the efficiency of acoustic desorption, , which can be attributed to higher amplitudes of compressive pressure pulses generated under conditions of spatial confinement in both ablative and nonablative irradiation conditions. − An alternative setup, where an absorbing metal layer (liquid mercury) is confined between two sapphire plates, has also been demonstrated to be effective for the generation of strong acoustic pulses leading to desorption of electrons, ions, and molecules. , Note that, while metal foils are used most commonly for the generation and transmission of acoustic pulses in LIAD, the acoustic desorption has also been reported from a Si substrate and the molecular sample itself …”